Different patterns of cortical gray matter loss over time in behavioral variant frontotemporal dementia and Alzheimer's disease

Neurobiology of Aging
Christiane MöllerWiesje M van der Flier

Abstract

We examined patterns of cortical thickness loss and cognitive decline over time in 19 patients with Alzheimer's disease (AD), 10 with behavioral variant frontotemporal dementia (bvFTD), and 34 controls with a mean interval of 2.1 ± 0.4 years. We measured vertexwise and regional cortical thickness changes of 6 lobar regions of interest between groups with the longitudinal FreeSurfer pipeline. Compared with controls, AD and bvFTD had a steeper rate of cognitive decline and showed faster cortical thinning per year. Decrease of thickness over time was highest in AD and generalized throughout the whole brain, most pronounced posteriorly, whereas bvFTD patients had a more selective loss in frontal cortex and in anterior parts of the temporal lobes. In a direct comparison, AD patients showed faster cortical thinning in the insula, temporal, and parietal regions, whereas bvFTD patients only showed faster cortical thinning in the orbitofrontal gyrus. Decline of cognitive performances was in line with cortical thinning and deteriorated the most in AD patients.

References

Aug 1, 1993·Archives of Neurology·J L Cummings
Dec 24, 1997·Journal of Magnetic Resonance Imaging : JMRI·N C Fox, P A Freeborough
Jun 12, 2002·Neurology·E RatnavalliJ R Hodges
Jun 5, 2004·Dementia and Geriatric Cognitive Disorders·Jennifer L WhitwellNick C Fox
May 11, 2005·Neurology·N C FoxUNKNOWN AN1792(QS-21)-201 Study
Jan 13, 2006·Neurobiology of Aging·Josephine BarnesNick C Fox
Nov 8, 2006·Topics in Magnetic Resonance Imaging : TMRI·Jennifer L Whitwell, Clifford R Jack
Feb 13, 2007·Brain : a Journal of Neurology·Giovanni B FrisoniPaul M Thompson
Mar 10, 2007·Brain : a Journal of Neurology·Jennifer L WhitwellKeith A Josephs
Mar 14, 2007·NeuroImage·Simona M BrambatiMaria Luisa Gorno-Tempini
Jan 2, 2008·American Journal of Alzheimer's Disease and Other Dementias·G D RabinoviciH J Rosen
Feb 13, 2008·Archives of Neurology·William W SeeleyMaria Luisa Gorno-Tempini
May 7, 2008·Neurology·J D SluimerW M van der Flier
Apr 2, 2009·Psychological Medicine·A E van der VliesW M van der Flier
Jul 3, 2009·Alzheimer Disease and Associated Disorders·Casey E KruegerJoel H Kramer
Jul 21, 2009·European Radiology·Jasper D SluimerFrederik Barkhof
Oct 23, 2009·Neurology·C A RajiJ T Becker
Jun 1, 2010·Brain Structure & Function·William W Seeley
Jul 20, 2010·NeuroImage·Martin ReuterBruce Fischl
Mar 8, 2011·NeuroImage·Martin Reuter, Bruce Fischl
Aug 4, 2011·Brain : a Journal of Neurology·Katya RascovskyBruce L Miller
Aug 16, 2011·Biochimica Et Biophysica Acta·Jonathan D Rohrer
Mar 21, 2012·NeuroImage·Martin ReuterBruce Fischl
Jun 23, 2012·Dementia and Geriatric Cognitive Disorders·Ping Lei PanHui Fang Shang
Apr 9, 2013·Neurobiology of Aging·Christiane MöllerWiesje M van der Flier
Nov 12, 2013·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Lieke L SmitsWiesje M van der Flier
Apr 22, 2015·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Lieke L SmitsWiesje M van der Flier

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Citations

Dec 29, 2016·Headache·Franz RiedererPeter S Sándor
Jan 6, 2017·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Sander C J VerfaillieWiesje M van der Flier
Jul 12, 2018·IEEE Reviews in Biomedical Engineering·Stephanos LeandrouConstantinos S Pattichis
Dec 22, 2019·Brain Structure & Function·L JänckeS Merillat
Aug 10, 2016·Journal of Neurochemistry·Elizabeth GordonNick C Fox
Jun 14, 2019·Reviews in the Neurosciences·Jessica OschwaldSusan Mérillat
Oct 28, 2019·Frontiers in Genetics·Xia-An BiYingchao Liu
May 24, 2020·Journal of Alzheimer's Disease : JAD·Nicolas NicastroJohn T O'Brien
Mar 23, 2018·Journal of Alzheimer's Disease : JAD·Wiesje M van der Flier, Philip Scheltens
Mar 29, 2019·NeuroImage. Clinical·Ellen DicksUNKNOWN Alzheimer's Disease Neuroimaging Initiative
May 4, 2021·Frontiers in Human Neuroscience·Christiane JockwitzSvenja Caspers
Jul 13, 2021·Frontiers in Neuroscience·Bijia Song, Jun-Chao Zhu
Jul 17, 2021·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Kamalini G RanasingheKatherine P Rankin

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