Different patterns of gamma delta and alpha beta T cell redistribution in the mouse after partial gastrectomy

The Journal of Surgical Research
A GryglewskiW Ptak

Abstract

Stress, including surgical trauma, results in different dysfunctions of the body. In our former experiments on posttraumatic modification of immune response of gastrectomized mice we observed a significant suppression of contact sensitivity. This could be transferred by lymph nodes and spleen T lymphocytes of mice which underwent surgery. We studied changes in gammadelta and alphabeta T cell numbers in peripheral blood, Peyer's patches, and mesenteric lymph nodes after partial gastrectomy (major operation) and after sham gastrectomy (laparotomy-minor operation) in mice. The number of gammadelta and alphabeta T cells was counted on the FACSTAR cell sorter before and 1, 2, 3, 7, and 14 days after surgery. In our observations there was a significant increase of percentage of gammadelta T cells both in Peyer's patches (1.9 +/- 0.5 to 10.5 +/- 0.3) and in mesenteric lymph nodes (2.7 +/- 0.7 to 8.8 +/- 3.5) on the third day after partial gastrectomy (546 and 322% of control values, respectively). In contrast in gastrectomized mice the number of alphabeta T cells in Peyer's patches (38.4 +/- 6.8 to 21.2 +/- 6.2) and lymph nodes (56.7 +/- 15 to 40.4 +/- 17) was decreased on day 3 (55 and 71% of control values, respectively). There was ...Continue Reading

References

Jul 1, 1990·Immunology Today·P M Lydyard, W van Eden
Apr 1, 1995·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·P ToftE Tønnesen
Jan 1, 1993·Annual Review of Immunology·W HaasS Tonegawa

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Citations

Apr 10, 2008·Journal of Clinical Biochemistry and Nutrition·Mariko MurakamiHiroaki Masunaga
Apr 21, 2004·Immunology·Mark HirshMichael M Krausz
Mar 26, 1999·The Journal of Surgical Research·M M BuzdonB L Bass
Oct 1, 2019·ANZ Journal of Surgery·Andrzej GryglewskiMarian Szczepanik
Oct 7, 2004·The Journal of Nutrition·Anna Pérez-BosqueMiquel Moretó
Jul 22, 2021·Archivum Immunologiae Et Therapiae Experimentalis·Andrzej GryglewskiMarian Szczepanik

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