Different patterns of H2S/NO activity and cross-talk in the control of the coronary vascular bed under normotensive or hypertensive conditions

Nitric Oxide : Biology and Chemistry
L TestaiV Calderone

Abstract

Hydrogen sulfide (H2S) and nitric oxide (NO) play pivotal roles in the cardiovascular system. Conflicting results have been reported about their cross-talk. This study investigated their interplays in coronary bed of normotensive (NTRs) and spontaneously hypertensive rats (SHRs). The effects of H2S- (NaHS) and NO-donors (sodium nitroprusside, SNP) on coronary flow (CF) were measured in Langendorff-perfused hearts of NTRs and SHRs, in the absence or in the presence of propargylglycine (PAG, inhibitor of H2S biosynthesis), L-NAME (inhibitor of NO biosynthesis), ODQ (inhibitor of guanylate cyclase), L-Cysteine (substrate for H2S biosynthesis) or L-Arginine (substrate for NO biosynthesis). In NTRs, NaHS and SNP increased CF; their effects were particularly evident in Angiotensin II (AngII)-contracted coronary arteries. The dilatory effects of NaHS were abolished by L-NAME and ODQ; conversely, PAG abolished the effects of SNP. In SHRs, high levels of myocardial ROS production were observed. NaHS and SNP did not reduce the oxidative stress, but produced clear increases of the basal CF. In contrast, in AngII-contracted coronary arteries of SHRs, significant hyporeactivity to NaHS and SNP was observed. In SHRs, the vasodilatory effects...Continue Reading

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Citations

Oct 21, 2016·Antioxidants & Redox Signaling·Denis FeliersBalakuntalam S Kasinath
Mar 11, 2017·American Journal of Physiology. Gastrointestinal and Liver Physiology·Amanda R JensenTroy A Markel
Mar 3, 2019·British Journal of Pharmacology·Alma MartelliVincenzo Calderone
Jun 17, 2020·Journal of Cellular Physiology·Yuqi ChenXiang Zhou
Dec 2, 2020·Expert Opinion on Drug Discovery·Alma MartelliVincenzo Calderone
Oct 25, 2016·Physiological Research·I BernátováI Sekaj
Dec 19, 2016·Inorganic Chemistry·T Spencer BaileyMichael D Pluth

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