PMID: 9557737Apr 29, 1998Paper

Different patterns of neuronal infection after intracerebral injection of two strains of pseudorabies virus

Journal of Virology
J P CardL W Enquist

Abstract

Pseudorabies virus (PRV), a swine neurotropic alphaherpesvirus, is known to invade the central nervous system (CNS) of a variety of animal species through peripherally projecting axons, replicate in the parent neurons, and then pass transsynaptically to infect other neurons of a circuit. Studies of the human pathogen herpes simplex virus type 1 have reported differences in the direction of transport of two strains of this virus after direct injection into the primate motor cortex. In the present study we examined the direction of transport of virulent and attenuated strains of PRV, utilizing injections into the rat prefrontal cortex to evaluate specific movement of virus through CNS circuitry. The data demonstrate strain-dependent patterns of infection consistent with bidirectional (anterograde and retrograde) transport of virulent virus and unidirectional (retrograde) transport of attenuated PRV from the site of injection. The distribution of infected neurons and the extent of transsynaptic passage also suggest that a release defect in the attenuated strain reduces the apparent rate of viral transport through neuronal circuitry. Finally, injection of different concentrations of virus influenced the onset of replication within ...Continue Reading

Citations

Jun 27, 2001·Nature Neuroscience·G Aston-JonesM L Oshinsky
Oct 17, 2008·The Journal of Comparative Neurology·Michael A LanePaul J Reier
Jun 4, 2013·Journal of the Association for Research in Otolaryngology : JARO·M Christian BrownDaniel J Lee
Sep 12, 2019·Frontiers in Neuroscience·Christine SaleebaSimon McMullan
Jun 16, 2001·Journal of Biological Rhythms·T J BartnessG E Demas
Jan 19, 2005·The European Journal of Neuroscience·Magdalene J SeilerRobert B Aramant
May 29, 2009·Neuropathology and Applied Neurobiology·S SisóL González
Jun 26, 2012·Annual Review of Microbiology·Gregory Smith
Feb 26, 2013·Viruses·Tal Kramer, Lynn W Enquist
Apr 23, 2008·Current Protocols in Neuroscience·J P Card, L W Enquist
Apr 22, 2009·PLoS Pathogens·Joy I LeeGregory A Smith
Jun 1, 2005·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Hyung Bin ParkBonghee Lee
Jul 11, 2000·Journal of Virology·C E SaldanhaH M Friedman
Dec 6, 2002·Microscopy Research and Technique·Ida GerendaiBéla Halász
Jul 6, 2014·Current Protocols in Neuroscience·J Patrick Card, Lynn W Enquist
May 23, 2015·Journal of Virology·Gina R DanielGregory A Smith
Jan 20, 2006·Experimental Brain Research·Brent A MettsAdrian A Perachio
Oct 29, 2003·Journal of Virology·Amanda C ClaseBruce W Banfield

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