PMID: 9450625Feb 5, 1998Paper

Different patterns of soluble adhesion molecules in systemic and cutaneous lupus erythematosus

Experimental Dermatology
F NybergE Stephansson

Abstract

Circulating isoforms of cellular adhesion molecules (CAMs) have been described recently, and elevated levels of certain sCAMs have been reported in various inflammatory diseases such as systemic lupus erythematosus (SLE). There are previously no reports on sCAMs in cutaneous LE. Sera from 61 patients with LE: systemic (SLE: n=24), chronic cutaneous (discoid LE, DLE: n= 19) or subacute cutaneous (SCLE: n=8), chronic biologically false positive (CBFP) reactors for syphilis (n= 10) and 32 controls were examined for sICAM-1, sVCAM-1 and sE-Selectin with specific ELISA kits. Protocol forms were reviewed. We found significantly elevated levels of sE-Selectin in patients with DLE and widespread cutaneous symptoms, and a correlation between active cutaneous disease as well as polymorphous light eruption (PLE) and elevated levels of sE-Selectin. In contrast, patients with systemic LE did not have elevated levels of sE-Selectin, but in concordance with earlier reports, sICAM-1 and sVCAM-1 levels were elevated compared to controls in SLE, as well as in SCLE patients, which has not been reported previously. Since activated endothelial cells are the only source for E-Selectin, the elevated sE-Selectin level in patients with widespread and a...Continue Reading

References

Jul 1, 1992·Experimental Dermatology·A BudnikJ Krutmann
Mar 1, 1992·Immunology Today·Y ShimizuS Shaw
Nov 1, 1982·Arthritis and Rheumatism·E M TanR J Winchester
Oct 1, 1993·Immunology Today·A J Gearing, W Newman
Jan 1, 1995·Dermatology : International Journal for Clinical and Investigative Dermatology·L KowalzickJ Ring
Jan 1, 1995·Dermatology : International Journal for Clinical and Investigative Dermatology·C BonifatiF Ameglio
Apr 1, 1995·British Medical Bulletin·P T Chapman, D O Haskard
Oct 1, 1994·Journal of the American Academy of Dermatology·H IhnK Takehara
Jul 1, 1993·Clinical Immunology and Immunopathology·P P SfikakisG C Tsokos
Sep 1, 1995·Journal of Dermatological Science·H MoritaN Kawasaki
Nov 1, 1995·British Journal of Rheumatology·C P DentonC M Black
Jul 4, 1996·The New England Journal of Medicine·P S Frenette, D D Wagner

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.