Different pediatric brain tumors are associated with different gene expression profiling

Acta histochemica
Michelino Di RosaLucia Malaguarnera

Abstract

Malignant brain tumors are the most common pediatric solid tumors and are the leading cause of death from childhood cancers. These tumors include several histologic subtypes. Due to the particular properties of brain tumors, such as growth and division, examination of brain tumors and the analysis of results are not simple. Up to date there is a dearth of useful biomarkers that have been validated and clinically implemented for pediatric brain tumors. In order to identify the new genetic alterations we recognized, using microarray dataset, chitinases as new potential biomarkers of CNS tumors. The modulation of chitinases was confirmed also in the different histologic subtypes. Our study revealed that distinct patterns of chitinases expression characterize the diverse histological subtypes. In addition evaluating other lisosomal enzymes such as glycosidases and proteases we found that NEU4, CTBS and GBA2 belonging to glycosidases family and CTSC, CTSK and CTSF belonging to proteases family were differently modulated. Future investigations are needed to be performed before some of these enzymes could finally be used as biomarkers of specific types of CNS neoplasms.

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Citations

Dec 22, 2015·Immunobiology·Michelino Di RosaLucia Malaguarnera
Sep 14, 2015·Acta histochemica·Paolo FagoneGaetano Magro
Nov 26, 2015·Neurochemical Research·Aureli MassimoSonnino Sandro
Apr 22, 2015·Acta histochemica·Gaetano MagroRosalba Parenti
Sep 23, 2016·Journal of the Neurological Sciences·C SanfilippoM Di Rosa
May 8, 2018·Disease Models & Mechanisms·Ilaria GregorioMatilde Cescon
Feb 29, 2020·Molecular Neurobiology·Carlo Castruccio CastracaniGiovanni Li Volti
Jul 25, 2020·Journal of Molecular Neuroscience : MN·Cristina SanfilippoMichelino Di Rosa
Jun 6, 2020·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Paola CatrogiovanniMichelino Di Rosa
Oct 27, 2017·Brain Sciences·Elias J Sayour, Duane A Mitchell
Apr 24, 2021·IScience·Shyong Quan YapRobert Joseph Huber
Oct 16, 2020·Journal of Molecular Neuroscience : MN·Cristina SanfilippoMichelino Di Rosa

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