Different Phenotypes of Non-Steroidal Anti-Inflammatory Drug Hypersensitivity during Childhood

International Archives of Allergy and Immunology
O CavkaytarOzge Soyer

Abstract

Although non-steroidal anti-inflammatory drug hypersensitivity (NSAID-H) has been widely studied in adults, there is still a lack of data regarding the features and phenotypes of NSAID-H in children. Our aim was to define risk factors and different phenotypes according to clinical patterns. Patients with a history of reaction to any NSAIDs referred between January 2012 and October 2014 were included. After completing a European Network for Drug Allergy (ENDA) questionnaire, initial skin and/or oral provocation tests (OPTs) were performed for the offending drug. Additional OPTs were done with aspirin in case of NSAID-H to determine cross-reactivity. NSAID-hypersensitive patients were defined as being either a selective responder (SR) or cross-intolerant (CI) and further categorized according to either the ENDA/GA2LEN classification or an alternative scheme by Caimmi et al. [Int Arch Allergy Immunol 2012;159:306-312]. Among 121 patients [58.7% male, average age 7.8 years (4.7-10.8)] with 161 NSAID-related reactions, 110 patients with 148 reactions were assessed. NSAID-H was diagnosed in 30 (27%) patients with 37 (25%) reactions. Multivariate regression analysis revealed that an immediate-type reaction and respiratory symptoms dur...Continue Reading

Citations

Aug 1, 2016·Allergologia et immunopathologia·C AlvesP Leiria-Pinto
Jan 4, 2017·International Archives of Allergy and Immunology·Eva Rebelo GomesUNKNOWN Portuguese Society of Allergology and Clinical Immunology (SPAIC) Drug Allergy Interest Group
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Jun 10, 2017·Current Opinion in Allergy and Clinical Immunology·Bernard Y-H Thong, Miguel Blanca
Jul 6, 2017·International Journal of Molecular Sciences·Ozge SoyerBulent Enis Sekerel
Apr 26, 2018·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Mona KidonMarina Atanaskovic-Markovic
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