Different physiological MRI noise between cortical layers

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
Galit Pelled, Gadi Goelman

Abstract

Significantly higher temporal fluctuations of the blood oxygenation level-dependent (BOLD) signal in the living rat group compared to that in the dead rat group were observed in the cortex, suggesting the existence of physiological information in the signal fluctuations. A similar analysis shows significantly different fluctuations between visual cortical layers. The highest fluctuations were observed in layers 4 and 5 and the lowest in layer 1. Given the consistency with published electrophysiology studies anticipating high spontaneous activity in the deeper layers (particularly layer 4), and low activity in superficial layers, we hypothesize that the BOLD signal temporal fluctuations may reflect cortical neuronal activity. Temporal fluctuations in ultrahigh spatial resolution data of the rat brain were measured in two ways. In the first, analyses were performed according to known layer widths, and in the second equal lines of 117 micro along the cortex were selected. The second approach yielded temporal fluctuations along the cortex that resemble known neuronal density distributions including the intralayer structure, particularly within layer 5.

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Citations

Aug 13, 2014·Brain Connectivity·James S Hyde, Rupeng Li
Jan 12, 2011·Biochemical Pharmacology·Unal SakoğluFeng Luo
Oct 26, 2007·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Anne C ZappeJozien B M Goense
Jul 24, 2008·Human Brain Mapping·Tao WuPiu Chan
Jun 10, 2009·Human Brain Mapping·Vesa KiviniemiOsmo Tervonen
Feb 23, 2011·NeuroImage·Peter J KoopmansDavid G Norris
Oct 15, 2013·Journal of Affective Disorders·Ke XuFei Wang
Jul 30, 2014·NeuroImage·Pei-Jung TsaiChing-Po Lin
Oct 14, 2016·Brain Imaging and Behavior·Chiara SarappaMario Quarantelli
Sep 1, 2007·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Zeev Gideon KipervaserGadi Goelman
May 6, 2008·Human Brain Mapping·Vesa Kiviniemi
Jul 21, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Robert L Barry, Ravi S Menon
Dec 19, 2020·Epilepsy & Behavior : E&B·Kristin E WillsDario J Englot

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