Different prolactin, thyrotropin, and thyroxine responses after prolonged intermittent or continuous infusions of thyrotropin-releasing hormone in rhesus monkeys

The Journal of Clinical Endocrinology and Metabolism
K PavasuthipaisitH G Spies

Abstract

Serum PRL, TSH, and T4 secretion during prolonged continuous or intermittent iv infusions of TRH were studied in 14 adult ovariectomized rhesus monkeys (Macaca mulatta). For 9 days, TRH was administered intermittently at 0.33 or 3.3 micrograms/min for 6 of every 60 min and continuously at 0.33 micrograms/min. With both modes, the PRL levels and responsiveness to TRH simulation peaked on day 1 and then fell to levels that were still higher than the preinfusion values; levels for the intermittently treated group on days 3-9 were 2- to 4-fold above prestimulation levels and significantly (P less than 0.01) higher than levels for the continuously treated group. Elevated basal levels and PRL responses to TRH pulses were similar during the 0.33 and 3.3 micrograms/min pulses of the 9-day treatment period. For both TRH modes, TSH levels were elevated significantly (P less than 0.001) on day 1 [this increase was higher with continuous infusion (P less than 0.001)] and then fell to preinfusion levels by day 3. Serum T4 also increased during both continuous and intermittent TRH stimulations. However, serum T4 levels were significantly lower (P less than 0.01) after intermittent TRH (both 0.33 and 3.3 micrograms/min) than after continuous ...Continue Reading

Citations

Jan 1, 1993·Thyroid : Official Journal of the American Thyroid Association·M H SamuelsE C Ridgway
Oct 1, 1987·Journal of Neurology, Neurosurgery, and Psychiatry·R J GuiloffS L Lightman
Oct 23, 2008·Endocrine Reviews·Johannes D VeldhuisSteven M Pincus
Jan 1, 1988·Annals of the New York Academy of Sciences·T L MunsatI M Jackson
Jul 27, 2017·General and Comparative Endocrinology·Bridget MartinezRudy M Ortiz

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