Different protective effects of tauroursodeoxycholate, ursodeoxycholate, and 23-methyl-ursodeoxycholate against taurolithocholate-induced cholestasis

Digestive Diseases and Sciences
U BaumgartnerE H Farthmann

Abstract

The coinfusion of tauroursodeoxycholate (TUDC) prevents taurolithocholate (TLC) -induced cholestasis. 23-Methyl-ursodeoxycholate (MUDC) is a side-chain derivative of ursodeoxycholate (UDC). If conjugation with taurine is important for the protective effect of UDC, the MUDC may not be as able as TUDC to prevent TLC-induced cholestasis since it is poorly amidated by the liver. To answer this question, isolated livers of adult Sprague-Dawley rats were coinfused with MUDC (UDC, TUDC) and TLC. After 15 min, inflow rates of the bile acids were doubled. In further experiments taurine in excess was added to the coinfused bile acids. The uptake of bile acids was >90% in all groups, irrespective of whether they were perfused alone or in combination. Single perfusion of TLC caused a rapid decrease in bile flow. UDC and MUDC were hypercholeretic; TUDC moderately choleretic. During coinfusion experiments, TUDC not only completely abolished cholestasis but in addition increased bile flow and biliary bile acid secretion. UDC did prevent TLC cholestasis at the lower inflow rates. At high inflow rates, bile flow decreased significantly. Addition of taurine to this bile acid combination did not significantly improve the anticholestatic effect of...Continue Reading

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Citations

Nov 26, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·U BeuersG Paumgartner
Jan 27, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P MilkiewiczR Coleman
Feb 24, 2001·Journal of Gastroenterology and Hepatology·D Kumar, R K Tandon
May 1, 1997·Journal of Pediatric Gastroenterology and Nutrition·W F Balistreri
Aug 8, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F HolzingerA F Hofmann
Jun 15, 2010·Biochemical and Biophysical Research Communications·Yeon Yi LeeKyong Soo Park
Dec 14, 2011·Reproduction in Domestic Animals = Zuchthygiene·J-S KimD-B Koo
Jan 1, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·Gianfranco AlpiniGene LeSage

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