PMID: 8595652Dec 1, 1995Paper

Different respiratory-defective phenotypes of Neurospora crassa and Saccharomyces cerevisiae after inactivation of the gene encoding the mitochondrial acyl carrier protein

Current Genetics
R SchneiderH Weiss

Abstract

The nuclear genes (acp-1, ACP1) encoding the mitochondrial acyl carrier protein were disrupted in Neurospora crassa and Saccharomyces cerevisiae. In n. crassa acp-1 is a peripheral subunit of the respiratory NADH : ubiquinone oxidoreductase (complex I). S. cerevisiae lacks complex I and its ACP1 appears to be located in the mitochondrial matrix. The loss of acp-1 in N. crassa causes two biochemical lesions. Firstly, the peripheral part of complex I is not assembled, and the membrane part is not properly assembled. The respiratory ubiquinol : cytochrome c oxidoreductase (complex III) and cytochrome c oxidase (complex IV) are made in normal amounts. Secondly, the lysophospholipid content of mitochondrial membranes is increased four-fold. In S. cerevisiae, the loss of ACP1 leads to a pleiotropic respiratory deficient phenotype.

References

Aug 1, 1992·Quarterly Reviews of Biophysics·J E Walker
May 1, 1992·Plant Molecular Biology·A R Slabas, T Fawcett
May 8, 1991·European Journal of Biochemistry·H WeissD Preis
Jan 1, 1990·Annual Review of Genetics·D A Hopwood, D H Sherman
Jan 26, 1990·European Journal of Biochemistry·S Mikolajczyk, S Brody
Jun 12, 1985·Biochimica Et Biophysica Acta·G Daum
Jan 1, 1986·Cold Spring Harbor Symposia on Quantitative Biology·C T Caskey
Apr 15, 1988·European Journal of Biochemistry·S Brody, S Mikolajczyk
Feb 1, 1971·Analytical Biochemistry·C W McClare
May 1, 1970·European Journal of Biochemistry·H WeissT Bücher
Jan 1, 1983·Methods in Enzymology·R J Rothstein
Jun 5, 1983·Journal of Molecular Biology·D Hanahan
Aug 12, 1983·Journal of Chromatography·H P Nissen, H W Kreysel
Jan 1, 1994·Methods in Enzymology·G van Ginkel, A Sevanian
Aug 1, 1993·Journal of Bioenergetics and Biomembranes·T FriedrichH Weiss
Jan 1, 1993·FEMS Microbiology Reviews·M Göttfert

❮ Previous
Next ❯

Citations

Jun 20, 2008·Molecular Genetics and Genomics : MGG·Claire RemaclePatrice P Hamel
Jul 14, 2006·Journal of Inherited Metabolic Disease·Rolf J R J JanssenJan A M Smeitink
Sep 11, 2002·Biochimica Et Biophysica Acta·Arnaldo Videira, Margarida Duarte
Mar 5, 2003·Journal of Molecular Biology·Tomi T AirenneJ Kalervo Hiltunen
May 30, 2001·Advanced Drug Delivery Reviews·I E Scheffler
Jun 6, 2000·Microbiology and Molecular Biology Reviews : MMBR·V Contamine, M Picard
Jun 8, 2006·Annual Review of Biochemistry·Ulrich Brandt
Jan 31, 2008·BMC Cell Biology·Xiaomin ZhangJeanne Y Wei
Feb 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·H WadaJ Ohlrogge
Jun 26, 2014·Journal of Bioenergetics and Biomembranes·Margarida Duarte, Ana M Tomás
Sep 17, 2015·Current Genetics·Dongmei LiRichard Calderone
Mar 20, 2012·Neurobiology of Disease·Rainer ProhaskaRuth H Walker
Jan 5, 2011·Fungal Genetics and Biology : FG & B·Gethin AllenGeoffrey Turner
Sep 25, 2004·Molecular Microbiology·Alexander J KastaniotisJ Kalervo Hiltunen
May 3, 2005·Biochimica Et Biophysica Acta·Isabel MarquesArnaldo Videira
Sep 5, 2006·Biochimica Et Biophysica Acta·Oksana TehlivetsSepp D Kohlwein
Apr 22, 2005·Journal of Molecular Biology·Toni GabaldónMartijn A Huynen
Jul 3, 2003·Biochimica Et Biophysica Acta·Judy HirstJohn E Walker
Sep 26, 2013·Biochemical Society Transactions·Katarzyna Kmita, Volker Zickermann
Mar 17, 2010·Biochimica Et Biophysica Acta·J Kalervo HiltunenAlexander J Kastaniotis
Sep 22, 2009·Biochimica Et Biophysica Acta·Krzysztof DobryninUlrich Brandt
Dec 4, 2004·Biochimica Et Biophysica Acta·Immo E SchefflerPrasanth Potluri
Sep 15, 2007·Biochimica Et Biophysica Acta·Rutger O VogelLeo G J Nijtmans
Oct 11, 2016·Cell Metabolism·Sergio Guerrero-CastilloLeo Nijtmans
Dec 15, 2006·The Journal of Biological Chemistry·Jennifer L StephensPaul T Englund
Jul 3, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Zhijun ChenJ Kalervo Hiltunen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.