Different response of osteoblastic cells to Mg(2+), Zn(2+) and Sr(2+) doped calcium silicate coatings

Journal of Materials Science. Materials in Medicine
Dandan HuXuebin Zheng

Abstract

Mg(2+), Zn(2+) and Sr(2+) substitution for Ca(2+) in plasma sprayed calcium silicate (Ca-Si) coatings have been reported to impede their degradation in physiological environment and, more importantly, to improve their biological performance. The reason for the improved biological performance is still elusive and, especially, the contribution of the dopant ions is lack of obvious and direct evidence. In this study, we aim to identify the effect of Mg(2+), Zn(2+) and Sr(2+) incorporation on the osteogenic ability of Ca-Si based coatings (Ca2MgSi2O7, Ca2ZnSi2O7 and Sr-CaSiO3) by minimizing the influence of Ca and Si ions release and surface physical properties. Similar surface morphology, crystallinity and roughness were achieved for all samples by optimizing the spray parameters. As expected, Ca and Si ions release from all the coatings showed the comparable concentration with immersing time. The response of MC3T3-E1 cells onto Mg(2+), Zn(2+) and Sr(2+) doped Ca-Si coatings were studied in terms of osteoblastic adhesion, proliferation, differentiation and mineralization. The results showed that the level of cell adhesion and proliferation increased the most on the surface of Mg-modified coating. Gene expressions of early markers ...Continue Reading

References

Jan 1, 1996·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·K KieswetterB D Boyan
Jan 23, 1999·Calcified Tissue International·S L HallJ R Farley
Aug 25, 1999·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·A Rezania, K E Healy
May 5, 2001·Bone·S G DahlC Christiansen
Sep 5, 2002·Journal of Biomedical Materials Research·H ZreiqatM Shakibaei
Oct 9, 2002·Calcified Tissue International·R K RudeB G Mills
Mar 27, 2004·Metabolism: Clinical and Experimental·A BarbaraP J Marie
Sep 1, 2004·Bone·S Pors Nielsen
Jan 31, 2006·Journal of Biomaterials Applications·Chengtie Wu, Jiang Chang
Jun 13, 2006·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Siyu NiWanyin Zhai
Aug 4, 2006·Journal of Biomedical Materials Research. Part a·Weichang XueKeith D K Luk
Apr 3, 2007·Chemico-biological Interactions·Valentina AinaDario Ghigo
Oct 31, 2007·Journal of Biomedical Materials Research. Part a·Chengtie WuHala Zreiqat
Mar 11, 2008·Molecular and Cellular Biochemistry·Masayoshi YamaguchiTaeko Nakagawa
Sep 6, 2008·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Xuanyong LiuBaoe Li
Feb 25, 2011·Acta Biomaterialia·Ming-You ShieHsien-Chang Chang
Jul 24, 2012·Pharmacology & Therapeutics·Zuzana Saidak, Pierre J Marie

❮ Previous
Next ❯

Citations

Apr 25, 2018·Journal of Tissue Engineering and Regenerative Medicine·Yao WangChangyi Li
May 8, 2019·Biomaterials Science·Xinchen WuGulden Camci-Unal
Dec 13, 2019·Biomedical Engineering Online·Su WangYongqiang Hao
May 16, 2020·Materials·J Patrick O'ConnorJessica A Cottrell

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.