Different responses of circulating ghrelin, obestatin levels to fasting, re-feeding and different food compositions, and their local expressions in rats

Peptides
Zhi-Fu GuoLin Zou

Abstract

Obestatin, a sibling of ghrelin derived from preproghrelin, opposes several physiological actions of ghrelin. Our previous study has demonstrated that both plasma ghrelin and obestatin levels were decreased significantly 2h after food intake in human. To further expand current knowledge, we investigated the temporal profiles of their levels in ad libitum fed rats, 48h fasted rats and 48h fasted rats refed 2h with a standard chow, crude fiber, 50% glucose or water, and their expressions in stomach, liver and pancreatic islets immunohistochemically. Plasma ghrelin and obestatin levels were measured by EIA. Plasma leptin, insulin and glucose levels were also evaluated. Both plasma ghrelin and obestatin levels increased significantly in fasted rats compared with ad libitum fed rats. The ingestion of standard chow produced a profound and sustained suppression of ghrelin levels, whereas plasma obestatin levels decreased significantly but recovered quickly. Intake of crude fiber or 50% glucose, however, produced a more profound and sustained suppression of obestatin levels, though they had relatively less impact on ghrelin levels. Plasma glucose was the only independent predictor of ghrelin levels, obestatin levels, and ghrelin to obe...Continue Reading

References

Mar 13, 2001·Biochemical and Biophysical Research Communications·K ToshinaiS Matsukura
Apr 5, 2002·The Journal of Clinical Endocrinology and Metabolism·A CaixásB Laferrère
Jun 18, 2003·Endocrinology·Diana L WilliamsJoel M Kaplan
Oct 4, 2003·Endocrinology·Diana L WilliamsJoel M Kaplan
Nov 7, 2003·The Journal of Clinical Endocrinology and Metabolism·Palmiero MonteleoneMario Maj
Nov 25, 2003·Diabetes·Giuseppe MurdoloPierpaolo De Feo
Dec 23, 2003·Regulatory Peptides·Guillermo GomezGeorge H Greeley
Jan 13, 2004·The Journal of Clinical Endocrinology and Metabolism·Jean L ChanChristos S Mantzoros
Mar 6, 2004·The Journal of Clinical Endocrinology and Metabolism·Holly S CallahanDavid S Weigle
Jun 8, 2004·The Journal of Clinical Endocrinology and Metabolism·Johannes ErdmannVolker Schusdziarra
Nov 6, 2004·Endocrinology·Joost OverduinDavid E Cummings
Dec 24, 2005·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·S PavlatosN Katsilambros
Jan 26, 2006·The Journal of Clinical Endocrinology and Metabolism·Jane BowenPeter M Clifton
Mar 11, 2006·Endocrinology·Thomas O MundingerGerald J Taborsky
Jun 30, 2006·Neuroscience Letters·Eva Szentirmai, James M Krueger
Aug 3, 2006·The Journal of Clinical Endocrinology and Metabolism·P MarzulloA Liuzzi
Sep 30, 2006·Endocrinology·Rubén NogueirasCarlos Diéguez
Oct 13, 2006·Journal of Endocrinological Investigation·L M SeoaneF F Casanueva
Oct 13, 2006·Journal of Endocrinological Investigation·E BrescianiA Torsello
Nov 8, 2006·The Journal of Endocrinology·Siok L DunNae J Dun
Dec 13, 2006·Biochemical and Biophysical Research Communications·Valeria P CarliniSusana R Debarioglio
Dec 23, 2006·Journal of Cellular Physiology·Jesus P CamiñaFelipe F Casanueva
Jan 6, 2007·Endocrinology·Philippe ZizzariMarie Thérèse Bluet-Pajot
Feb 15, 2007·The Journal of Clinical Endocrinology and Metabolism·Zhi-Fu GuoZheng Zhang
Feb 16, 2007·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·B De SmetI Depoortere
Apr 10, 2007·Biochemical and Biophysical Research Communications·Guy J LagaudNigel P Shankley
Oct 2, 2007·Animal Reproduction Science·M MészárosováF Valenzuela
Dec 18, 2007·Biochemical and Biophysical Research Communications·ShreeRanga NagarajUma V Manjappara

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Citations

Apr 15, 2014·Archivum Immunologiae Et Therapiae Experimentalis·Flavia Prodam, Nicoletta Filigheddu
Sep 11, 2012·Neuroscience Letters·Rong-Guo FuYarong Wang
Apr 5, 2011·Molecular and Cellular Endocrinology·Inge SeimLisa Chopin
Jan 5, 2010·Metabolism: Clinical and Experimental·Abbass Ghanbari-NiakiRobert R Kraemer
Aug 12, 2009·Cytokine & Growth Factor Reviews·Inge SeimLisa K Chopin
Nov 4, 2008·Peptides·Xiao-Ying DongXiao-Ting Zou
Jun 3, 2008·Biochemical and Biophysical Research Communications·Abbass Ghanbari-NiakiHojatollah Nikbakht
Nov 26, 2015·Pregnancy Hypertension·Weiguang WuYingchun Wang
Sep 3, 2013·Molecular and Cellular Endocrinology·Darko StevanovicTamara R Castañeda
Dec 30, 2009·Pharmacological Reviews·Chih-Yen ChenAkio Inui
Jun 8, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Giuseppe AlloattiGiampiero Muccioli
Jul 28, 2010·The Journal of Clinical Endocrinology and Metabolism·Christina MaierAnton Luger
Mar 13, 2009·Acta Biochimica Et Biophysica Sinica·Xuefeng YinWeizhen Zhang
Jun 23, 2020·International Journal of Endocrinology·Yonas AkaluBirhanu Ayelign
Mar 7, 2019·Journal of the Chinese Medical Association : JCMA·Hsien-Hao Huang, Chih-Yen Chen

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