Different responses of E:Z-isomers of pesticides in liquid chromatography-electrospray ionization-mass spectrometry

Journal of Mass Spectrometry : JMS
Bernhard Mayer-HelmJutta Pani

Abstract

The mass spectrometric behavior of four pairs of stereoisomers was investigated by liquid chromatography-electrospray ionization-mass spectrometry (LC-ESI-MS). The E- and Z-isomers of the pesticides chlorfenvinphos, dimethomorph, mevinphos and phosphamidon-each with one double bond-were chosen for this study. The MS response of the individual isomers was investigated by infusing the isomers individually into the MS or after the separation of isomer mixtures via high-performance liquid chromatography (HPLC). In the case of dimethomorph, the same MS response was found for the two isomers. In contrast to that, the individual isomers of chlorfenvinphos, mevinphos and phosphamidon showed different MS response both in the single ion monitoring (SIM) mode in single quadrupole MS and multiple reaction monitoring (MRM) mode in tandem MS. The MS response of the isomers partly depends on (1) the declustering potential of the precursor ion in the SIM mode, (2) the selected transition and (3) the collision energy in the MRM mode. Consequently, quantification by summation of the peak areas of the isomers is inaccurate due to over- or underestimating of one of the stereoisomers. Accurate quantitative results can only be achieved when the comp...Continue Reading

References

Aug 11, 2000·Journal of the American Society for Mass Spectrometry·T KuuranneR Kostianen
Apr 21, 2001·Journal of Agricultural and Food Chemistry·M J Hengel, T Shibamoto
Mar 15, 2003·Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan·Masahiro OkihashiShinjiro Hori
Dec 17, 2008·Journal of the American Society for Mass Spectrometry·Yoko OhashiYoshitaka Nagai

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Citations

Feb 23, 2021·Journal of Chromatographic Science·Madeleine WernethHerwig Stepan
Mar 4, 2011·Current Opinion in Allergy and Clinical Immunology

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