Different responses of gonadotropin-releasing hormone (GnRH) release to glutamate receptor agonists during aging

Brain Research Bulletin
M A SortinoP L Canonico

Abstract

GnRH release from hypothalamic explants from young and aged male Wistar-Kyoto rats was evaluated following stimulation with glutamate receptor agonists. Glutamate stimulated GnRH release to a similar extent in hypothalami from young and old animals, whereas N-methyl-D-Aspartate (NMDA) and kainate appeared more efficacious in young and old rats, respectively. Old rats were unable to respond to a maximal stimulating concentration of glutamate when they had been previously exposed to a challenge with the same agent. These results demonstrate that responsiveness to glutamate receptor agonists changes during aging, suggesting the involvement of distinct glutamate receptors in the control of GnRH release during different phases of lifespan.

References

Sep 1, 1986·Endocrinology·L T JarjourR S Swerdloff
Jan 21, 1983·European Journal of Pharmacology·J R Unnerstall, J K Wamsley
Nov 1, 1993·The Journal of Endocrinology·A M Cowell
May 1, 1992·Trends in Endocrinology and Metabolism : TEM·D W Brann, V B Mahesh

❮ Previous
Next ❯

Citations

Dec 13, 2000·Experimental Gerontology·J D Veldhuis
Oct 16, 2004·The Journal of Clinical Endocrinology and Metabolism·Johannes D Veldhuis, Ali Iranmanesh
Jul 27, 1999·General and Comparative Endocrinology·K M FlynnS P Banerjee
Mar 3, 2004·Annals of the New York Academy of Sciences·Valérie MatagneJean-Pierre Bourguignon
Jul 19, 2013·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Svetlana TsesisAlexander Zlotnik
May 14, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Peter Y LiuJohannes D Veldhuis
Dec 13, 2005·American Journal of Physiology. Endocrinology and Metabolism·Peter Y LiuJohannes D Veldhuis

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.