PMID: 8604011Mar 1, 1996Paper

Different responses of plasma ACTH and corticosterone and of plasma interleukin-1 beta to single and recurrent endotoxin challenges

Journal of Leukocyte Biology
M MekaoucheG Ixart

Abstract

In a parallel study in 10 individual rats, three time series of plasma concentrations of ACTH, corticosterone (CORT), and interleukin-1 beta (IL-1 beta) were measured before (time 0) and at intervals between 15 and 480 min following intra-arterial (i.a.) infusions of 25 microgram/kg lipopolysaccharide (LPS). All LPS injections were given at 9 AM. The first time series was performed on naive rats (day 1). A sequence of six daily injections (days 3-8) of the same dose of LPS followed. The post-LPS time course of the plasma ACTH, CORT and IL-1 beta levels were studies on days 3 (second injection) and 8 (seventh injection). The first LPS injection induced a rapid (30 min) eightfold rise in plasma ACTH and CORT, culminating in concentrations 30 times the baseline at 60 min (ACTH) and 15 times baseline at 120 min (CORT). Both hormones receded back to the initial basal level at 480 min. On the other hand, IL-1 beta increased slowly to peak at 13 times baseline 120 min before declining to minimal seven- to ninefold basal levels, 480 min and even 48 h post-LPS. During the second phase of the experiment starting 48 h after the initial LPS priming sequence, the ACTH and CORT responses to daily recurrent LPS injections again differed from ...Continue Reading

Citations

Jan 26, 1999·Annals of the New York Academy of Sciences·E Zeisberger, J Roth
Aug 3, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jennifer C Felger, Michael T Treadway
Jan 26, 1999·Annals of the New York Academy of Sciences·W KozakH Zheng
Jan 22, 1998·The American Journal of Physiology·M J LenczowskiF J Tilders

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