PMID: 8970949Dec 1, 1996Paper

Different roles for CD4+ and CD8+ T lymphocytes and macrophage subsets in the control of a generalized virus infection

Journal of Virology
Gunasegaran KarupiahJ Chen

Abstract

The importance of T-lymphocyte subsets in the control of poxvirus infections is controversial. To determine the relative contribution of lymphocyte subsets important for recovery from infection with ectromelia virus (EV), a natural murine poxvirus pathogen, C57BL/6 (B6) mice lacking functional CD8+ T cells because of disruption of the beta2-microglobulin gene or lacking functional CD4+ T cells because of disruption of the I-(A)beta gene, acutely depleted of CD8+ or CD4+ T cells with monoclonal antibody, or depleted of macrophage subsets by the macrophage suicide technique were used. Recovery from infection was strictly dependent on the effector functions of CD8+ T cells, in the absence of which 100% mortality resulted. This lymphocyte population had demonstrable antiviral activity early in the infection process even before class I major histocompatibility complex (MHC)-restricted CD8+ cytotoxic T-lymphocyte (CTL) activity was detectable. CD4+ T cells were found to be necessary for the generation of an optimal virus-specific, class I MHC-restricted CD8+ CTL response and contributed to virus clearance not involving cytolytic mechanisms. In both models of CD4+ T-cell deficiency, virus clearance was incomplete and persisted at low ...Continue Reading

References

Dec 21, 1978·Nature·J R Bennink, P C Doherty
Jul 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·M K SpriggsC R Maliszewski
Mar 1, 1991·Microbiological Reviews·R M Buller, G J Palumbo
Jan 1, 1991·Annual Review of Immunology·R M Steinman
Jan 1, 1990·European Journal of Immunology·M R Kohonen-CorishI A Ramshaw
Jan 1, 1989·Advances in Immunology·T R Mosmann, R L Coffman
Apr 1, 1989·The Journal of Experimental Medicine·S JonjićU H Koszinowski
Oct 1, 1987·The Journal of General Virology·H C O'Neill, M Brenan
Sep 1, 1983·Infection and Immunity·H C O'Neill, R V Blanden
Jun 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·J KapplerP Marrack
Sep 1, 1995·The Journal of Experimental Medicine·M J Bevan
Jul 1, 1993·Journal of Virology·G KarupiahR M Buller
Dec 1, 1994·Immunology Today·M Clerici, G M Shearer
Jan 1, 1994·Annual Review of Immunology·P Matzinger
Sep 14, 1994·Journal of Immunological Methods·N Van Rooijen, A Sanders
Aug 1, 1993·Current Opinion in Immunology·P C Doherty
Jan 12, 1996·Science·R M Zinkernagel
Jan 10, 1996·Cellular Immunology·M BattegayR M Zinkernagel
Mar 1, 1996·Immunology Today·T R Mosmann, S Sad

❮ Previous
Next ❯

Citations

Mar 8, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·T L BornR M Buller
Jul 6, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·J C Gea-BanaclocheM Connors
Jun 26, 2002·Viral Immunology·Peter Kerr, Grant McFadden
Jun 24, 2003·Reviews in Medical Virology·Arno Müllbacher
Jul 19, 2003·Proceedings of the National Academy of Sciences of the United States of America·Igor M BelyakovJay A Berzofsky
Dec 30, 2004·The Journal of Experimental Medicine·David C TscharkeJonathan W Yewdell
Jun 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Richard P CiavarraChristina Steel
Jan 19, 2007·Journal of Virology·Isaac G SakalaGunasegaran Karupiah
Feb 13, 2008·PLoS Pathogens·Min FangLuis J Sigal
Oct 17, 2007·PLoS Pathogens·J Mauricio Calvo-CalleLawrence J Stern
Jul 30, 2010·Journal of Applied Microbiology·L SzulcM G Niemialtowski
Jul 9, 2011·PloS One·Sophie DuraffourGraciela Andrei
Jun 24, 2020·Proceedings of the National Academy of Sciences of the United States of America·Ma Junaliah Tuazon KelsGunasegaran Karupiah
Nov 14, 1997·The Journal of Experimental Medicine·J RubyJ J Peschon
Sep 20, 2000·The Journal of General Virology·S J TurnerJ Ruby
May 24, 2001·Proceedings of the National Academy of Sciences of the United States of America·S MahalingamP S Foster
Jun 30, 2001·International Immunology·J D AhlersJ A Berzofsky
Feb 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anuja MathewJeffrey S Kennedy
Sep 10, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·William G GlassPhilip M Murphy
May 4, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lichen JingDavid M Koelle
Oct 10, 2007·Immunology and Cell Biology·Vijay PanchanathanGunasegaran Karupiah
Jan 2, 2007·Reviews in Medical Virology·Richard Kennedy, Gregory A Poland
Feb 15, 2008·The Journal of General Virology·April Keim ParkerR Mark L Buller
Apr 12, 2007·Viral Immunology·A Ferrier-RembertJ-M Crance
Nov 23, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lichen JingDavid M Koelle
Sep 24, 2010·Future Microbiology·Clement A Meseda, Jerry P Weir
Jun 16, 2006·Journal of Virology·David C TscharkeJonathan W Yewdell
Jul 25, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·John GouldingShahram Salek-Ardakani

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.