PMID: 7528770Jan 1, 1995Paper

Different roles for the Fc epsilon RI gamma chain as a function of the receptor context

The Journal of Experimental Medicine
R PaoliniJ P Kinet

Abstract

The high affinity immunoglobulin E receptor (Fc epsilon RI) and the B and T cell antigen receptors (TCR) are multimeric complexes containing subunits with cytoplasmic antigen recognition activation motifs (ARAMs). The presence of multiple motifs may be a way to amplify a single signal or provide independent activation modules. Here we have compared the signaling capacity of the same Fc epsilon RI gamma motif in the context of two different receptors, Fc epsilon RI and TCR/CD3, simultaneously reconstituted on the surface of the same zeta-deficient T cell line. Both reconstituted receptors mediate early (phosphorylation) and late (interleukin [IL]-2 release) signals. Mutation of the two tyrosine residues of ARAM gamma alters early signaling by both receptors, but the set of substrates phosphorylated via ARAM gamma is different for each receptor and is thus dependent on the receptor context. Furthermore, the mutations prevent Fc epsilon RI- but not TCR/CD3-mediated IL-2 release. These data demonstrate that ARAM gamma is necessary for allowing both receptors to phosphorylate the complete set of substrates, and that the CD3 complex, unlike the Fc epsilon RI beta chain, contains activation modules capable of compensating for the abse...Continue Reading

References

Oct 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·J E HutchcroftJ M Oliver
Feb 1, 1992·Immunological Reviews·H Metzger
Oct 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·A C ChanA Weiss
May 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·T KurosakiJ V Ravetch
Feb 1, 1991·Current Opinion in Immunology·S KoyasuE L Reinherz
Oct 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·F Letourneur, R D Klausner
Jun 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·L E SamelsonR D Klausner
Jan 1, 1990·Annual Review of Cell Biology·R D KlausnerJ S Bonifacino
Mar 30, 1989·Nature·M Reth
Jul 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·L K ErnstC L Anderson
May 1, 1993·The Journal of Experimental Medicine·T W SalcedoB Perussia

❮ Previous
Next ❯

Citations

Mar 6, 2010·International Urogynecology Journal·Ling-Hong TsengChyi-Long Lee
Dec 1, 1996·Current Opinion in Immunology·M A Beaven, R A Baumgartner
Jan 1, 1997·Annual Review of Immunology·M Daëron
Jan 21, 1997·Proceedings of the National Academy of Sciences of the United States of America·C P LiuP Marrack
Jan 1, 1996·International Reviews of Immunology·T Takai
Mar 1, 1997·European Journal of Immunology·W A JensenJ C Cambier
Jan 1, 1997·International Reviews of Immunology·M Daëron
Jun 22, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·T SuzukiZ Honda
Aug 7, 1999·The Journal of Biological Chemistry·P G SwannJ Rivera
Jul 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·T A BorkowskiJ P Kinet
Jul 26, 1996·The Journal of Biological Chemistry·J GibbinsS P Watson
Feb 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Daiju SakuraiTakashi Saito

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.