PMID: 9184800May 1, 1997Paper

Different roles of endothelium-derived substances on inhibiting platelet aggregation in whole blood

General Pharmacology
M KurataM Usami

Abstract

1. The inhibitory effects of adenosine, nitroprusside (a nitric oxide donor) and prostacyclin on collagen-induced rabbit platelet aggregation were studied under two different conditions: in whole blood with an impedance method and in platelet-rich plasma (PRP) with a turbidimetric method. 2. All substances tested were less potent in whole blood than in PRP, and the differences in IC50 value between whole blood and PRP were not of the same order of magnitude; adenosine (669-fold), nitroprusside (54-fold) and prostacyclin (2-fold). 3. These results imply that (a) some other, as yet unknown, factors in blood modulate the platelet aggregation; (b) adenosine and nitric oxide act close to the endothelium, and (c) prostacyclin acts as a relatively long lasting circulating hormone.

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Citations

Mar 17, 2004·The Journal of Toxicological Sciences·Masaaki Kurata, Ikuo Horii
Jul 9, 2003·Critical Care Medicine·Jens M KlingeJörg Dötsch

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