Different roles of PPAR-γ activity on physiological and pathological alteration after myocardial ischemia

Journal of Cardiovascular Pharmacology
Ayako NagashimaMitsuaki Isobe

Abstract

Telmisartan is an angiotensin II receptor blocker, which acts as a partial agonist of peroxisome proliferator activator receptor-γ (PPAR-γ). Because PPAR-γ initiates a variety of antiinflammatory responses, the effect on myocardial ischemia is to be elucidated. The left anterior descending arteries were ligated to induce myocardial infarction in rats. The animals were assigned to 4 groups: (1) control (saline, n = 6), (2) telmisartan (10 mg·kg·d, n = 6), (3) telmisartan + GW9662 (PPAR-γ-antagonist) (10 mg·kg·d of telmisartan and 1 mg·kg·d of GW9662, n = 6), and (4) amlodipine (10 mg·kg·d, n = 8) groups. Telmisartan reduced mean blood pressure compared with that in the control group. There was no statistical difference among the telmisartan, telmisartan + GW9662 and amlodipine groups. The end-diastolic left ventricular diameter was smaller in telmisartan group compared with that in the control group; GW9662 negated the effect of telmisartan. The thickness of the ventricular septum was kept in the telmisartan group compared with that in the control group; GW9662 negated the effect. Histopathologic analyses showed that telmisartan suppressed myocardial fibrosis compared with that of the control, whereas GW9662 negated the telmisar...Continue Reading

References

Nov 18, 1991·The American Journal of Cardiology·P AnversaJ M Capasso
Feb 16, 2005·The Journal of Clinical Investigation·Shin-ichiro MatsumuraYasunori Okada
Dec 13, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Marina R BergmanDavid H Lovett
Apr 18, 2008·Journal of Cardiovascular Pharmacology·Binhui Liang, Frans H H Leenen
Apr 26, 2008·American Journal of Hypertension·Naohiko KobayashiHiroaki Matsuoka
Mar 24, 2010·Chemico-biological Interactions·Sameer GoyalDharamvir Singh Arya

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Citations

Aug 8, 2015·Neurourology and Urodynamics·Kenichi MoriNaoki Yoshimura
Jun 18, 2017·Frontiers in Pharmacology·Benita L McVicker, Robert G Bennett
Oct 7, 2020·Pharmacology & Therapeutics·Qirong LuMaría-Aránzazu Martínez

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