Different roles of related currents in fast and slow spiking of model neurons from two phyla.

Journal of Neurophysiology
En HongAstrid A Prinz

Abstract

Neuronal activity arises from the interplay of membrane and synaptic currents. Although many channel proteins conducting these currents are phylogenetically conserved, channels of the same type in different animals can have different voltage dependencies and dynamics. What does this mean for our ability to derive rules about the role of different types of ion channels in neuronal activity? Can results about the role of a particular channel type in a particular type of neuron be generalized to other neuron types? We compare spiking model neurons in two databases constructed by exploring the maximal conductance spaces of two models. The first is a model of crustacean stomatogastric neurons, and the second is a model of rodent thalamocortical neurons, but both models contain similar types of membrane currents. Spiking neurons in both databases show distinct fast and slow subpopulations, but our analysis reveals that related currents play different roles in fast and slow spiking in the stomatogastric versus thalamocortical neurons. This analysis involved conductance-space visualization and comparison of voltage traces, current traces, and frequency-current relationships from all spiker subpopulations. Our results are consistent wit...Continue Reading

References

Oct 1, 1992·Journal of Neurophysiology·J R Huguenard, D A McCormick
Oct 1, 1992·Journal of Neurophysiology·D A McCormick, J R Huguenard
Feb 1, 1992·Journal of Neurophysiology·J Golowasch, E Marder
Mar 1, 1988·Journal of Neurophysiology·D A McCormick, D A Prince
Feb 1, 1971·The Journal of Physiology·J A Connor, C F Stevens
May 1, 1981·The Journal of Physiology·D DiFrancesco
Apr 1, 1984·The Journal of Physiology·H Jahnsen, R Llinás
Feb 1, 1996·Journal of Neurophysiology·G G TurrigianoL F Abbott
Feb 5, 2002·Journal of Neurophysiology·Jorge GolowaschEve Marder
Mar 22, 2002·Pflügers Archiv : European journal of physiology·Jürgen KupperPeter Fromherz
Nov 24, 2004·Nature Neuroscience·Astrid A PrinzEve Marder
Apr 2, 2005·The Journal of Experimental Biology·Yuri V Panchin
Aug 11, 2005·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Andrey ShilnikovGennady Cymbalyuk
Sep 16, 2005·Journal of Neurophysiology·Charles J Wilson, Joshua A Goldberg
May 12, 2006·Journal of Neurophysiology·Adam L TaylorEve Marder
Mar 16, 2007·IEEE Transactions on Visualization and Computer Graphics·Jing YangWilliam Ribarsky

❮ Previous
Next ❯

Citations

Feb 28, 2013·Network : Computation in Neural Systems·Cyrus P BillimoriaJohn T Birmingham

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.