Different spexin level in obese vs normal weight children and its relationship with obesity related risk factors

Nutrition, Metabolism, and Cardiovascular Diseases : NMCD
Maryam BehroozAlireza Ostadrahimi

Abstract

Spexin (SPX) is a novel peptide recently discovered as an important regulatory adipokine in obesity and related metabolic diseases. The aim of the current study was to determine the potential role of Circulating levels of SPX in obese children and explore its relationships with obesity-related risk factors, and its potential role in preventing obesity. Forty-five obese children and 45 normal-weight children of similar age and sex, with mean age of 13.73 (2.68) were recruited in this Study. Weight and height, blood pressure, resting metabolic rate (RMR), physical activity level, stress, anxiety and depression, appetite status, daily energy intake, pubertal stage, serum Spexin, Interleukin-10 (IL-10), IL-1β, high-sensitivity C-reactive protein (hs-CRP), fasting glucose, insulin and lipid profile, were measure during standard techniques. Median (IQR) of Spexin levels were significantly lower in obese vs. normal-weight children [120.70 (77.7) pg/mL vs.145 (186.7)pg/mL; P = 0.03]. Based on the tertiles of the serum Spexin levels, a protective independent effect was observed for the highest tertile of serum Spexin concentrations. Crude OR (CI): 0.33 (0.11-0.95), P-trend = 0.04. Model 1 OR (CI): 0.20 (0.05-0.73), P- trend = 0.01, Mode...Continue Reading

Citations

Dec 22, 2020·Diabetes Research and Clinical Practice·Maryam BehroozAlireza Ostadrahimi
Sep 21, 2020·General and Comparative Endocrinology·Ewa Pruszynska-OszmalekPawel Antoni Kolodziejski
Apr 15, 2021·European Journal of Clinical Nutrition·Nouran Y SalahYasmin G El Gendy
Jul 14, 2021·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Seema KumarP Babu Balagopal

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