Different structural remodelling in atrial fibrillation with different types of mitral valvular diseases

Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology
Yongjun QianXijun Xiao

Abstract

The aim of this study was to determine the relationship between atrial structural remodelling and atrial fibrillation (AF) for different types of mitral valvular diseases (MVDs). Left atrial appendages tissue samples were obtained from 24 patients with MVDs undergoing mitral valve replacement surgery. Masson's trichrome staining and immunohistochemical staining were performed to assess the extent of the fibrosis. Ultrastructural changes in left atrial appendages were examined by electron microscope. The degree of fibrosis showed significant increases in patients with AF compared with patients with sinus rhythm (SR) (P = 0.023). The collagen volume fraction (CVF) of fibrosis significantly increased in mitral stenosis and atrial fibrillation (MS-AF) compared with the mitral regurgitation and atrial fibrillation (MR-AF) group (P = 0.043). Collagen Type I levels were significantly increased in AF patients with mitral stenosis compared with AF patients with mitral regurgitation (P = 0.043). Different CVF of Matrix metalloproteinases-2 was present between the MS-SR group and the MS-AF group (P = 0.001). Electron microscopy revealed normally structured sarcomeres with a predominance of loosely packed cardiomyocytes in samples from pat...Continue Reading

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Citations

Jun 15, 2012·Cardiology in Review·Hadewich HermansPeter Verhamme
Oct 29, 2013·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Liang ZhaoXu Liu
Nov 5, 2013·The Journal of Thoracic and Cardiovascular Surgery·Niv AdSari D Holmes
Mar 31, 2012·The Annals of Thoracic Surgery·Anna Olasinska-WisniewskaTomasz Podzerek
Feb 7, 2012·The Annals of Thoracic Surgery·Lindsey L SaintHersh S Maniar
Apr 12, 2014·Interactive Cardiovascular and Thoracic Surgery·Hrvoje GasparovicBojan Biočina
Feb 7, 2012·International Journal of Cardiology·Tanima BanerjeeArun Bandyopadhyay
Nov 7, 2016·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Shuenn-Nan ChiuJou-Kou Wang
Nov 3, 2017·Journal of cardiovascular ultrasound·Hyoeun KimEui-Young Choi
May 5, 2016·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Shu-Ling DiaoXian-Liang Liu
Oct 11, 2017·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Patrick MüllerPhilipp Halbfass

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