Different susceptibility to insulin resistance and fatty liver depending on the combination of TNF-α C-857T and adiponectin G+276T gene polymorphisms in Japanese subjects with type 2 diabetes

The Tohoku Journal of Experimental Medicine
Mio OharaJo Satoh

Abstract

The C-857T promoter polymorphism of TNF-α gene is associated with obese type 2 diabetes, while the adiponectin G+276T gene polymorphism in intron 2 may influence the fat accumulation in the liver. In this study, we examined effects of these polymorphisms on clinical markers of insulin resistance and fatty liver (a liver/spleen CT ratio < 0.9). These polymorphisms were determined in 342 Japanese subjects with type 2 diabetes. The liver/spleen CT ratio was lower in the subjects with the adiponectin +276G/G genotype than that in the subjects with the +276T allele (P < 0.05), indicating that fat accumulation in the liver is associated with the +276G/G genotype. Multiple comparisons among the 4 combinations of each polymorphism of the TNF-α and adiponectin genes revealed a significant difference in the liver/spleen CT ratio (P < 0.05) among the 4 groups, indicating that the gene combinations influence the degree of fat accumulation in the liver. The subjects carrying the TNF-α -857T allele (C/T or T/T genotype) and the adiponectin +276G/G genotype had greater risks for fatty liver and insulin resistance that was evaluated by higher levels of fasting insulin and homeostasis model assessment of insulin resistance, as compared wit...Continue Reading

References

Nov 25, 2003·Experimental Diabesity Research·Jo SatohTakayoshi Toyota
Sep 8, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Birgit GustafsonUlf Smith
Jun 2, 2009·Journal of Gastroenterology·Katsutoshi TokushigeKeiko Shiratori
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Apr 12, 2011·Expert Review of Gastroenterology & Hepatology·Herbert Tilg, Alexander R Moschen

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Citations

Feb 6, 2014·Journal of Endocrinological Investigation·S I Al-AzzamA Y Alhasan
Sep 24, 2013·Molecular Biology Reports·Madhukar SaxenaMonisha Banerjee

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