Different T cell antigens and receptors for peanut agglutinin and Helix pomatia agglutinin on steroid-sensitive and resistant lymphocytes in the rabbit using double immunofluorescence

Immunobiology
P Roholl, J Wormmeester

Abstract

Rabbit T lymphocytes were characterized using fluorochrome-labelled antisera against thymus cell determinants and fluorochrome-labelled lectins. Three anti-T cell antisera were used, detecting different antigenic determinants on the majority of T cells. Only small subpopulations were found stained by one of the three antisera. After dexamethasone (DX) treatment, the proportion of T cells was significantly increased in bone marrow and appendix, presumably by different mechanisms. Cells binding peanut agglutinin, mainly belonging to the T cell population, were present in small numbers in thymus, spleen, lymph node, and appendix from normal as well as from DX-treated animals. In bone marrow, however, a large PNA+ population showing neither T nor B cell surface properties was observed. After treatment with neuraminidase (NA), PNA binding sites were exposed on B as well as on an increased number of T cells. It is suggested, therefore, that T and B cells retained their PNA receptors during maturation. Masking of these receptors will take place before differentiation of T cells is initiated within the thymus. After NA treatment, also binding sites for Helix pomatia agglutinin were exposed on T cells and to different extents, revealing...Continue Reading

References

Apr 1, 1980·Cell·E L Reinherz, S F Schlossman

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Citations

May 1, 1984·Cell and Tissue Kinetics·P J Roholl, B Distel

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