PMID: 6968037Aug 28, 1980Paper

Different target antigens for T-cell subsets acting synergistically in vivo

Nature
E A Wolters, R Benner

Abstract

After allogenic transplantation of lymphoid cells into immunologically incompetent recipients, a graft-versus-host (GvH) reaction can occur. The original observation that the GvH reaction is mediated by two interacting types of T cell has led to the proposal that T cells must be subdivided into two subpopulations according to life span and migratory properties. These consist of T1 cells, which are short-lived, sessile cells sensitive to adult thymectomy (ATx), and T2 cells, which are long-lived, recirculating cells sensitive to anti-thymocyte serum (ATS). T1-T2 cooperation has also been demonstrated in vitro in murine and rat mixed lymphocyte culture. The question arises as to whether these T-cell subpopulations are activated by different or identical parts of the major histocompatibility complex (MHC). We report here that for optimal development of the anti-host immune response in a murine GvH reaction, T2 cells have to be amplified by T1 cells. The former cells are activated by a set of MHC gene products that are expressed mainly on immunological cells (H-2I-coded antigens), whereas the latter recognize a different set of MHC gene products that are expressed on almost all cells of the mouse (H-2K/D-coded antigens).

References

Jan 1, 1977·Contemporary Topics in Immunobiology·H Cantor, E Boyse
Mar 15, 1979·Cellular Immunology·P W WrightI D Bernstein
Jan 1, 1977·Cold Spring Harbor Symposia on Quantitative Biology·H Cantor, E A Boyse
Nov 2, 1978·Nature·R ScollayI Weissman

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Citations

Mar 1, 1982·Immunobiology·M H SchreierM J van Zwieten
Jun 1, 1986·Immunological Reviews·J SprentR Korngold

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