Different temperature thresholds for antipyretic intervention in critically ill children with fever due to infection: the FEVER feasibility RCT

Health Technology Assessment : HTA
Mark J PetersKathryn M Rowan

Abstract

Fever accelerates host immune system control of pathogens but at a high metabolic cost. The optimal approach to fever management and the optimal temperature thresholds used for treatment in critically ill children are unknown. To determine the feasibility of conducting a definitive randomised controlled trial (RCT) to evaluate the clinical effectiveness and cost-effectiveness of different temperature thresholds for antipyretic management. A mixed-methods feasibility study comprising three linked studies - (1) a qualitative study exploring parent and clinician views, (2) an observational study of the epidemiology of fever in children with infection in paediatric intensive care units (PICUs) and (3) a pilot RCT with an integrated-perspectives study. Participants were recruited from (1) four hospitals in England via social media (for the FEVER qualitative study), (2) 22 PICUs in the UK (for the FEVER observational study) and (3) four PICUs in England (for the FEVER pilot RCT). (1) Parents of children with relevant experience were recruited to the FEVER qualitative study, (2) patients who were unplanned admissions to PICUs were recruited to the FEVER observational study and (3) children admitted with infection requiring mechanical ...Continue Reading

Associated Clinical Trials

References

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Citations

Mar 8, 2020·JPEN. Journal of Parenteral and Enteral Nutrition·Lyvonne N TumeUNKNOWN Paediatric Intensive Care Society Study Group (PICS-SG)

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