Different types of acid-base changes at birth, fetal heart rate patterns, and infant outcome at 4 years of age

Acta Obstetricia Et Gynecologica Scandinavica
Andreas HerbstI Ingemarsson

Abstract

To study the relationship between different types of acidemia in umbilical artery blood at birth, fetal heart rate (FHR) patterns during labor, and infant long-term outcome. Case-control study of 48 infants with pure high base deficit (base deficit (BD) > or = 12 mmol/L and pCO2 < 8.0 kPa), 51 with mixed acidemia (BD > or = 12 mmol/L and pCO2 > or = 8.0 kPa), born at or after term, and controls matched for maternal age, parity, and gestational age at birth. FHR patterns during labor and the results of developmental screening at age 4 were compared between the groups. Late decelerations were associated with pure high base deficit and complicated variable decelerations with mixed acidemia. Both types of acidemia were correlated with Apgar scores below 7 at 1 minute, and mixed acidemia with more admissions to the neonatal intensive care unit. Developmental screening at age 4 years showed no significant differences between infants with mixed acidemia or pure high base deficit and controls. Twelve infants with mixed acidemia and six controls had deficits in language/speech development. Late decelerations may be an indicator of a metabolic component of acidemia and complicated variable decelerations an indicator of mixed acidemia. Th...Continue Reading

Citations

Jan 15, 2008·Journal de gynécologie, obstétrique et biologie de la reproduction·A Martin
Jul 15, 2011·Acta Obstetricia Et Gynecologica Scandinavica·Ayesha M F HeinisFred K Lotgering
Jun 9, 2004·Best Practice & Research. Clinical Obstetrics & Gynaecology·Lennart Nordström
Jun 21, 2014·American Journal of Obstetrics and Gynecology·Maria JonssonUlf Hanson

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