Different types of microsatellite instability in ovarian carcinoma

International Journal of Cancer. Journal International Du Cancer
Gad SingerHolger Moch

Abstract

Microsatellite instability at mono- and dinucleotide repeats is the hallmark of the hereditary non-polyposis cancer syndrome (HNPCC) and is related to deficient DNA mismatch repair. In contrast, a distinct form of microsatellite instability at selective tetranucleotide repeats (EMAST or elevated microsatellite alterations at selected tetranucleotides) was described in several non-HNPCC cancer types. EMAST is probably unrelated to mismatch repair defects. We investigated the frequency of microsatellite instability at mononucleotide, dinucleotide and tetranucleotide repeats in a series of 75 ovarian carcinomas (53 serous and 22 non-serous). Microsatellite analysis was carried out using 5 mono- and dinucleotide markers from the National Cancer Institute Consensus Panel and 6 tetranucleotide markers, which have been reported as frequently unstable in the literature. High frequency of microsatellite instability (MSI-H) at mono- and dinucleotide repeats was observed in 9% and a low frequency (MSI-L) in 21% of serous carcinomas. MSI-H was detected in 4% and MSI-L in 18% of non-serous carcinomas. Nine percent of serous carcinomas showed instability at multiple and 9% at single tetranucleotide loci. All non-serous carcinomas were stable...Continue Reading

Citations

Aug 23, 2006·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Maximilian BurgerRobert Stoehr
Oct 12, 2010·Journal of Genetic Counseling·Scott M WeissmanMolly S Daniels
Sep 17, 2010·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Bikash DevarajJohn M Carethers
Oct 21, 2005·The Journal of Molecular Diagnostics : JMD·Matthias WoenckhausWolfgang Dietmaier
May 29, 2007·The American Journal of Surgical Pathology·Matthias EiberArndt Hartmann
Mar 9, 2007·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·K DomanskaM Nilbert
Oct 17, 2008·Cancer Research·Astrid C HaugenMinoru Koi
Jan 7, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Jenny Permuth-WeyTuya Pal
Aug 2, 2006·BMC Cancer·Jozien HellemanEls M J J Berns
Mar 7, 2014·Genetic Testing and Molecular Biomarkers·Ji-Hyun LeeTuya Pal
Jan 18, 2006·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Matthias KloorNicolas Wentzensen
Dec 21, 2011·Digestive Diseases and Sciences·Ajay Goel
Nov 7, 2006·Cancer Treatment Reviews·Cara A Rabik, M Eileen Dolan
Mar 31, 2006·Human Immunology·Christine F W VermeulenGert Jan Fleuren
Feb 22, 2012·Biochimica Et Biophysica Acta·Jie LiHiromichi Hemmi
Aug 6, 2014·Gynecologic Oncology·Koah R VierkoetterKeith Y Terada
Dec 3, 2014·Gastroenterology·Stephanie S Tseng-RogenskiJohn M Carethers
Mar 2, 2012·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·Christine StoehrBernhard Walter
May 3, 2008·Yonsei Medical Journal·Bo-Sung YoonSunghoon Kim
Jul 15, 2005·Expert Review of Molecular Diagnostics·Matthias KloorJohannes F Gebert
Sep 18, 2020·Biomarkers in Medicine·Reza RanjbarSomayeh Mohammadpour
Sep 13, 2012·Oncology Letters·Leonardo Pandolfi CalimanAgnaldo Lopes DA Silva Filho
Dec 15, 2018·Journal of Cellular Physiology·Amir Torshizi EsfahaniHamid Asadzadeh Aghdaei
Jul 18, 2018·International Journal of Molecular Sciences·Anna Myriam PerroneGiuseppe Gasparre
Sep 9, 2021·PloS One·Siddharth JainJehoshua Bruck

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