PMID: 9533823Jun 1, 1997Paper

Different types of vasocontractile responses to noradrenaline in the presence of platelets with platelet activating factor

Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi
T Michibayashi

Abstract

Platelet activating factor (PAF) is known to produce a wide variety of hemodynamic effects. The present study was carried out with the aim of elucidating the mechanism of PAF action on vasoconstrictive response to noradrenaline (NA-R) in the presence of autologous platelets. NA-R was examined in isolated perfused arterial segments. PAF action through stimulation of platelets by noradrenaline (NA) was explored during infusion of platelet rich plasma (PRP) with PAF into the perfusion circuit. Consequently, it was revealed that PRP with PAF elicited an initially augmented response, followed by gradually attenuated responses under conditions of low doses of NA (in the range of 5 to 25 ng). However, the augmented responses were observed consistently under a higher dose of NA (50 ng). In addition, the gradually attenuated responses were reversed by adding tetrodotoxin, a Na-spike inhibitor. Thus, it is concluded that PAF action on NA-R through platelets may be related partly to neurotransmitters originating from perivascular autonomic depressant nerves stimulated by some neuroeffector agents.

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi
T Michibayashi
Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi
T Michibayashi
The Australian Journal of Experimental Biology and Medical Science
I S De La LandeB Waud
© 2022 Meta ULC. All rights reserved