PMID: 9159150May 27, 1997Paper

Differential ability of T cell subsets to undergo activation-induced cell death

Proceedings of the National Academy of Sciences of the United States of America
A S VaradhacharyP Salgame

Abstract

Human T cell clones were analyzed for their susceptibility to activation-induced cell death (AICD) in response to CD3/T cell receptor ligation. AICD was observed only in Th1 clones and was Fas-mediated, whereas Th2 clones resisted AICD. Analysis of a panel of Th0 clones, characterized by their ability to secrete both Th1 and Th2 cytokines, revealed that this subset included both AICD-sensitive (type A) and -resistant (type B) clones. Resistance to AICD by Th2 and Th0-type B clones was not due to lack of expression of either Fas receptor or its ligand. Paradoxically, the AICD-resistant clones were susceptible to apoptosis when Fas receptor was directly ligated by anti-Fas antibodies. However, prior activation of the resistant clones by monoclonal antibodies to CD3/TCR complex induced resistance against Fas-mediated apoptosis. Thus, the Fas-FasL pathway is critical for the induction of AICD in T cells, and moreover this pathway can be negatively regulated in the AICD-resistant clones by signals that are generated from ligation of the CD3/TCR complex.

References

Jan 1, 1992·Annual Review of Immunology·B R BloomP Salgame
Jan 1, 1992·Annual Review of Immunology·A Sher, R L Coffman
Dec 15, 1991·Journal of Immunological Methods·P Matzinger
Jan 1, 1988·Immunological Reviews·C A JanewayK Bottomly
Jan 1, 1989·International Immunology·P SalgameB R Bloom
Nov 21, 1995·Proceedings of the National Academy of Sciences of the United States of America·D AshanyK B Elkon
Dec 1, 1995·The Journal of Experimental Medicine·N KayagakiH Yagita
May 10, 1994·Proceedings of the National Academy of Sciences of the United States of America·S T JuA Marshak-Rothstein
Jun 1, 1994·Current Opinion in Immunology·J P Allison
Feb 2, 1995·Nature·J DheinP H Krammer
Mar 10, 1995·Science·S Nagata, P Golstein
Dec 1, 1994·Current Opinion in Immunology·G G SingerA K Abbas
Jan 1, 1994·Annual Review of Immunology·R A Seder, W E Paul
Jun 1, 1994·Current Opinion in Immunology·D R Green, D W Scott
Jan 1, 1994·Annual Review of Immunology·S Romagnani
Aug 30, 1994·Proceedings of the National Academy of Sciences of the United States of America·A K SimonJ Sieper
May 1, 1993·The Journal of Experimental Medicine·F P HeinzelM K Gately
Jul 1, 1993·Immunology Today·D KabelitzK Pechhold
Mar 1, 1993·Immunology Today·J J Cohen
Jan 1, 1993·Annual Review of Immunology·F W FitchT F Gajewski
May 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·J H RussellR Wang
May 1, 1996·The Journal of Experimental Medicine·L ZhangJ Zhang

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Citations

Sep 25, 2001·The Journal of Pathology·R J Glynne, S R Watson
Apr 16, 1998·Springer Seminars in Immunopathology·M R Alderson, D H Lynch
Aug 22, 2007·Cell Biochemistry and Biophysics·Alex Rabinovitch, Wilma L Suarez-Pinzon
Feb 21, 2004·Journal of Neuroimmunology·Stefan JungKlaus Toyka
Oct 10, 2002·Biochemical and Biophysical Research Communications·Yukiho ImaiTadahilo Oshida
Feb 13, 2001·Mechanisms of Ageing and Development·J D McLeod
May 17, 2003·Bulletin of Mathematical Biology·Can Keşmir, Rob J De Boer
May 5, 2001·Pharmacology & Therapeutics·K SharmaY F Shi
Dec 10, 1998·Immunity·G M Shearer
Jun 18, 2003·International Immunopharmacology·Baohui XuToru Takeuchi
Jun 17, 2008·Cell Death and Differentiation·G MelinoF Bernassola
Jun 20, 2007·Cell Research·Guangwu Xu, Yufang Shi
Sep 17, 2008·Immunology and Cell Biology·Esma S YolcuShai Yarkoni
Feb 24, 2001·Cell Research·T L Rothstein
Mar 8, 2002·Clinical and Experimental Immunology·H J AnkersmitG Boltz-Nitulescu
Aug 3, 1999·The Journal of Experimental Medicine·G A RabinovichY Chernajovsky
Jul 11, 2000·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·S Perdow-Hickman, P Salgame
Aug 26, 1998·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·P SalgameE E Henderson
Sep 3, 2002·Clinical and Diagnostic Laboratory Immunology·Judith J RyonDiane E Griffin
Mar 23, 2004·Annual Review of Immunology·Lauren CohnGeoffrey L Chupp
Oct 29, 2011·Molecular Medicine·Matthew W Klinker, Steven K Lundy
Mar 4, 2000·Proceedings of the National Academy of Sciences of the United States of America·I Suzuki, P J Fink
Nov 8, 2011·Infectious Disease Clinics of North America·Vidya SundareshanNancy Misri Khardori
May 11, 2005·Immunological Reviews·Hui-Chen HsuJohn D Mountz
Nov 10, 2010·European Journal of Immunology·Inka AlbrechtAndreas Radbruch
Dec 10, 2014·European Journal of Immunology·Claudia HaftmannMir-Farzin Mashreghi
Feb 22, 2008·Critical Reviews in Oncology/hematology·Dirk BrennerRüdiger Arnold
Sep 24, 2013·Veterinary Immunology and Immunopathology·Kumudika de SilvaDavid Emery
Jul 27, 2000·Seminars in Immunology·N A MitchisonB Chain
Apr 19, 2006·The Journal of Experimental Medicine·Jiankun TongAnne I Sperling

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