PMID: 758769Jan 1, 1979Paper

Differential accumulation of radiopaque contrast material in acute myocardial infarction

The American Journal of Cardiology
C B HigginsP T Siemers

Abstract

The differential accumulation of radiographic contrast materials in ischemically damaged and normal myocardium was assessed with direct measurement (fluorescent excitation analysis) of the iodine content of tissue samples from dogs with 48 hour old myocardial infarctions. Tissue samples were obtained 10, 30, 60 and 180 minutes after the intravenous administration of 2 ml/kg body weight of diatrizoate meglumine and sodium (Renografin-76). At all time intervals, the iodine concentration of infarcted tissue was at least threefold greater than that of normal myocardium. At 180 minutes the ratio between iodine concentration in infarcted myocardium and that in normal myocardium was 8.5 and between that in infarcted myocardium and that in blood was 2.6. The iodine concentration in the liver was similar to or greater than that in the infarcted area at time intervals after 10 minutes. These results suggest that the intravenous administration of contrast material may facilitate the identification of acutely infarcted myocardium with computerized X-ray transmission tomography.

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Citations

Jan 1, 1987·International Journal of Cardiac Imaging·M J Lipton
Jan 1, 1985·International Journal of Cardiac Imaging·J S GarrettM J Lipton
Jan 1, 1987·Cardiovascular and Interventional Radiology·M J Lipton
Mar 28, 2007·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Ricardo C CuryThomas J Brady
Aug 5, 2008·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Ricardo C CuryJack A Ziffer
Aug 6, 2000·European Journal of Radiology·M SaeedC B Higgins
Jan 24, 2007·AJR. American Journal of Roentgenology·Timo BaksPim J de Feyter
Nov 1, 1983·Clinical Radiology·S J BarterA Maseri
Mar 1, 1987·IEEE Transactions on Bio-medical Engineering·J J McInerneyM D Herr
Sep 1, 1982·IEEE Transactions on Bio-medical Engineering·M NassiP R Cipriano
Jan 1, 2008·JACC. Cardiovascular Imaging·Laurens F TopsJeroen J Bax
Apr 2, 2011·Expert Review of Cardiovascular Therapy·Andreas H Mahnken
Jan 1, 1994·IEEE Transactions on Medical Imaging·J J McInerneyM D Herr
Mar 21, 2007·Circulation·Marcelo F Di Carli, Rory Hachamovitch
Jul 31, 2007·Journal of Magnetic Resonance Imaging : JMRI·Albert de RoosJacob Geleijns
Aug 6, 2005·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Gabor F MatosFerdinand Leya
Oct 24, 2009·Nature Reviews. Cardiology·Karl H SchuleriAlbert C Lardo
Feb 22, 2012·Insights Into Imaging·Konstantin NikolaouBernd J Wintersperger

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