PMID: 3383848Jun 1, 1988Paper

Differential acetylation of core histones in rat cerebral cortex neurons during development and aging

European Journal of Biochemistry
B PiñaP Suau

Abstract

Core histones can be modified by aceylation and this modification has been correlated with the modulation of chromatin condensation and histone deposition. We have now studied the levels of acetylation of the core histones in rat brain cortical neurons from the middle of the period of neuronal proliferation through postnatal development and aging. The results show that the level of acetylation of H4 decreases with age. The kinetics of H4 deacetylation show a perinatal fast phase followed by a much slower phase that spans the rest of the period examined. H4 deacetylation is accounted for by the decrease of the monoacetylated species, the proportions of the more highly acetylated species remaining essentially constant. By contrast to histone H4, the overall levels of acetylation and the proportions of the different acetylated species of H2A, H2B and H3 remain unchanged throughout the period examined. Furthermore, the variants belonging to a given histone class always show the same level of acetylation. The fact that in neurons the level of monoacetylated H4 decreases during development and aging, in sharp contrast with the constancy of the levels of all other acetylated histone species, raises the possibility that in interphase c...Continue Reading

References

Jan 1, 1977·Annual Review of Biochemistry·O Hayaishi, K Ueda
Jan 1, 1978·Methods in Cell Biology·T A Langan
Mar 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·I L Goldknopf, H Busch
Aug 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·R B WallaceJ Bonner
Jan 1, 1979·Annual Review of Biochemistry·I Isenberg
Oct 12, 1979·Biochemical and Biophysical Research Communications·R Das, M S Kanungo
Apr 14, 1978·Biochemical and Biophysical Research Communications·M K ThakurM S Kanungo
Jul 11, 1977·Biochemical and Biophysical Research Communications·J A D'AnnaL R Gurley
Dec 17, 1985·Biochemical and Biophysical Research Communications·B Piña, P Suau
Apr 1, 1987·European Journal of Biochemistry·B PiñaP Suau
Dec 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·C D AllisI G Schulman
Sep 1, 1982·European Journal of Biochemistry·P D CaryG H Dixon

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Citations

May 11, 1990·Nucleic Acids Research·R OlivaG H Dixon
Aug 31, 2012·Epigenetics & Chromatin·Kévin ContrepoisCarl Mann
Aug 31, 2000·Biochemical and Biophysical Research Communications·S KyrylenkoA Salminen
Jul 17, 2014·The Proceedings of the Nutrition Society·Karen A LillycropGraham C Burdge
Nov 18, 2010·FEBS Letters·Jason Feser, Jessica Tyler
Jun 15, 2015·Progress in Neurobiology·Roy LardenoijeBart P F Rutten
Feb 28, 2018·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Jillian Belgrad, R Douglas Fields
Sep 26, 2007·Journal of Neuroscience Research·Hedi LiuPing Ye
Oct 12, 2017·Frontiers in Genetics·Corinne SidlerIgor Kovalchuk

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