PMID: 8971783Nov 22, 1996Paper

Differential action of 7-nitro indazole on rat brain nitric oxide synthase

Neuroscience Letters
B E KalischR J Boegman

Abstract

We examined the dose-response characteristics of brain nitric oxide synthase (NOS) inhibition following intraperitoneal administration of 7-nitro indazole (7-NI). 7-NI inhibited striatal, hippocampal, cortical, cerebellar and nigral NOS activity in a dose-dependent manner. NOS activity in the striatum and hippocampus could not be inhibited more than 60% while cerebellar and nigral activity was depleted by at least 85%, indicating that 7-NI has differential effects in different brain regions. ED50 values obtained from the 7-NI dose-response curves of the striatum and hippocampus were significantly higher than the ED50 values obtained from the cortex, cerebellum and substantia nigra, further confirming the differential actions of 7-NI. In addition, inhibition of NOS activity 4.5 h following a maximal dose of 7-NI demonstrated differential recovery. At this time point, the cerebellum and hippocampus were more inhibited than the striatum, cortex and substantia nigra. Therefore, the extent of recovery from this inhibition was independent of the level of maximal NOS inhibition in the different brain regions. We suggest determining the extent and duration of NOS inhibition resulting from 7-NI administration prior to using it to study ...Continue Reading

References

Jul 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·V L DawsonS H Snyder
Jan 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·D S Bredt, S H Snyder
Jul 9, 1991·European Journal of Pharmacology·G A BöhmeJ C Blanchard
Nov 1, 1994·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·T YoshidaM A Moskowitz
Feb 1, 1993·Pain·S T Meller, G F Gebhart

❮ Previous
Next ❯

Citations

Oct 10, 2009·Psychopharmacology·Kristina E HoqueAnthony R West
Mar 23, 2004·European Journal of Pharmacology·Mercedes FerrerGloria Balfagón
Jun 5, 2002·Neuroscience Letters·Pierangelo SardoVittorio La Grutta
Jul 17, 1999·Neuroscience·S BurletR Cespuglio
Mar 29, 2001·Brain Research Bulletin·R E HarlanM M Garcia
Jul 14, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Stephen SammutAnthony R West
May 4, 2004·Environmental Health Perspectives·Henry Lai, Narendra P Singh
Mar 4, 2005·Acta Physiologica Scandinavica·L JanssonO Källskog
Mar 29, 2008·The European Journal of Neuroscience·Janie M OndracekAnthony R West
Oct 6, 2009·Journal of Neurochemistry·Diana J Park, Anthony R West
Jun 3, 2014·Free Radical Biology & Medicine·Cátia F LourençoJoão Laranjinha
Jan 1, 1997·Nitric Oxide : Biology and Chemistry·E TalaveraM Condés-Lara
Nov 24, 2004·European Journal of Pharmacology·Yildirim SaraRustu Onur
May 28, 2004·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Andrew HarkinJohn P Kelly
Jan 17, 2017·Pituitary·Camila Henriques CoelhoMaria José Alves da Rocha
Apr 6, 2000·Journal of Applied Physiology·D D KlineN R Prabhakar
Oct 28, 2006·Journal of Applied Physiology·Michael Y SongLouis G D'Alecy
Apr 25, 2000·American Journal of Physiology. Heart and Circulatory Physiology·N C GocanK Tyml
Aug 12, 2003·Journal of Applied Physiology·Edwin R PriceKingman P Strohl
Apr 9, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Siroshini ThiagarajanThandar Ei

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.