Differential action of anti-emetic drugs on defecation and emesis induced by prostaglandin E2 in the ferret

European Journal of Pharmacology
Kelvin K W KanMan-K Wai

Abstract

In the present studies we investigated the mechanism of action of prostaglandin E2 (1 mg/kg, i.p.) to induce emesis and defecation and/or tenesmus in the ferret. The emesis was antagonized significantly (P<0.05) by ondansetron (0.3 and 1 mg/kg, i.p.) and (+)-(2S,3S)-3-(2-methoxybenzylamino)-2-phenlypiperidine hydrochloride (CP-99,994; 10 mg/kg, i.p.), but neither compound reduced defecations and/or tenesmus, with ondansetron (0.3 mg/kg) actually producing a slight increase (P<0.05). Droperidol (1 and 3 mg/kg), metoclopramide (0.3 and 3 mg/kg), domperidone (0.3 and 3 mg/kg), promethazine (0.3 and 3 mg/kg) and scopolamine (0.3 and 3 mg/kg) failed to reduce prostaglandin E2 induced emesis. However, droperidol (1 and 3 mg/kg) and scopolamine (0.3 and 3 mg/kg) reduced significantly the defecatory and/or tenesmus response (P<0.05). Bilateral abdominal vagotomy was ineffective to reduce emesis and defecations and/or tenesmus. The data suggests that 5-HT3 receptor and NK1 tachykinin receptor antagonists could be useful in the clinic to prevent emesis but not defecations induced by prostaglandin E2.

References

Feb 1, 1977·Prostaglandins·S M Karim, P G Adaikan
Jul 16, 1976·Naunyn-Schmiedeberg's Archives of Pharmacology·M Costa, J B Furness
Jan 1, 1992·Prostaglandins, Leukotrienes, and Essential Fatty Acids·V De SaedeleerA Houvenaghel
Feb 1, 1990·Canadian Journal of Physiology and Pharmacology·P L AndrewsL Maskell
Jan 1, 1989·Scandinavian Journal of Gastroenterology. Supplement·G Bianchi Porro, F Parente
Dec 1, 1986·Cellular and Molecular Neurobiology·D B Briggs, D O Carpenter
Jun 1, 1988·British Journal of Pharmacology·A ButlerM B Tyers
Mar 12, 1982·European Journal of Pharmacology·J H ZaveczT O Yellin
Dec 1, 1981·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·K Fahmy
Jan 1, 1982·Psychopharmacology·C J Niemegeers
Oct 26, 1995·Biochimica Et Biophysica Acta·M NegishiA Ichikawa
Jan 1, 1994·Fundamental & Clinical Pharmacology·J L MontastrucJ M Senard
Jun 1, 1994·Journal of Clinical Pharmacology·J J StewartM E Mims
Jul 20, 1993·European Journal of Pharmacology·T KamatoK Miyata
Apr 25, 1996·The New England Journal of Medicine·R K Goyal, I Hirano
Feb 1, 1996·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·T SatoS F Rabito
Jan 7, 1999·Cephalalgia : an International Journal of Headache·C G Dahlöf, R J Hargreaves
Feb 12, 2000·Trends in Pharmacological Sciences·N M Rupniak, M S Kramer
Jul 11, 2002·Life Sciences·Yukinori NagakuraTokio Yamaguchi
Oct 26, 2002·European Journal of Pharmacology·Kelvin K W KanJohn A Rudd
Jan 4, 2003·VASA. Zeitschrift für Gefässkrankheiten·M ReiterE Minar
Dec 9, 2003·European Journal of Pharmacology·Kelvin K W KanMan-K Wai
Apr 23, 2004·European Journal of Pharmacology·Kelvin K W KanJohn A Rudd
Mar 22, 2005·Journal of Magnetic Resonance Imaging : JMRI·Johannes M FroehlichKlaus-Ulrich Wentz

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Citations

Jul 12, 2008·Naunyn-Schmiedeberg's Archives of Pharmacology·Kelvin K W KanJohn A Rudd
Nov 28, 2009·European Journal of Pharmacology·Seetha CheboluNissar A Darmani
Dec 3, 2014·Biochemical and Biophysical Research Communications·Sojin KimYoung-Ho Jin
Apr 13, 2013·Journal of Pharmacological and Toxicological Methods·Sonia GoineauVincent Castagné
Mar 23, 2017·European Journal of Pharmacology·Kelvin K W KanJohn A Rudd
Jun 3, 2021·International Journal of Molecular Sciences·Weixia ZhongNissar A Darmani
Sep 28, 2021·Frontiers in Pharmacology·Weixia Zhong, Nissar A Darmani

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