Nov 18, 2008

Differential action of methylselenocysteine in control and alloxan-diabetic rabbits

Chemico-biological Interactions
Anna KiersztanJadwiga Bryla

Abstract

Antidiabetic action of inorganic selenium compounds is commonly accepted. Since in diet selenium mainly exists as selenoamino acids, potential hypoglycemic properties of methylselenocysteine (MSC) were investigated in four groups of rabbits: untreated and MSC-treated control animals as well as alloxan-diabetic and MSC-treated diabetic rabbits. MSC (at a dose of 1mg/kg body weight) was administered daily for 3 weeks via intraperitoneal injection. The data show, that in MSC-treated control animals plasma glucose concentration was diminished, while plasma urea and creatinine levels as well as urine albumin content were elevated and necrotic changes occurred in kidney-cortex. Decreased GSH/GSSG ratios in blood, liver and kidney-cortex were accompanied by increased glutathione peroxidase and glutathione reductase activities and a diminished renal gamma-glutamylcysteine synthetase activity. Death of 50% of control animals was preceded by a dramatic decline in blood glucose concentration. Surprisingly, in MSC-treated diabetic rabbits, plasma glucose levels were either normalized or significantly decreased. Blood and liver GSH/GSSG ratios were increased and renal functions were markedly improved, as indicated by a diminished albuminuri...Continue Reading

  • References46
  • Citations5

References

  • References46
  • Citations5

Citations

Mentioned in this Paper

Metabolic Process, Cellular
Ethylmaleimide
Glutamate-cysteine Ligase Activity
Necrosis
Urine
n-hexane
Kidney Function Tests
Creatinine
Phosphate buffers
Cortex Bone Disorders

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