Differential action of proteases from Trimeresurus malabaricus, Naja naja and Daboia russellii venoms on hemostasis

Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP
C D Raghavendra GowdaB S Vishwanath

Abstract

The action of venom proteases and their role in hemostasis has been compared in the venoms of Trimeresurus malabaricus, Daboia russellii and Naja naja from the Southern region of Western Ghats, India. These venoms exhibit varying amounts of proteolytic activity and also influence hemostasis differently. Casein hydrolyzing activity of T. malabaricus venoms was 16 and 24 fold higher than those of N. naja and D. russellii venoms, respectively. With the synthetic substrate TAME, the highest activity was observed in T. malabaricus venom. N. naja venom did not hydrolyze TAME even at higher concentrations. These variations in proteolytic activity also influenced the coagulation process. T. malabaricus and D. russellii venoms are strongly procoagulant and reduce the re-calcification time from 148 to 14 and 12 s, respectively. Similarly, both T. malabaricus and D. russellii venoms reduce the prothrombin time from 12.5 to 6.0 s. On the other hand, N. naja venom is anticoagulant and prolongs re-calcification time to 600 s and prothrombin time to 42 s. In spite of varied effects on hemostasis, all the venoms hydrolyze fibrinogen. T. malabaricus venom hydrolyses both Aalpha and Bbeta subunits. While D. russellii and N. naja venoms hydrolyse...Continue Reading

References

Jan 1, 1976·Methods in Enzymology·K Stocker, G H Barlow
Feb 20, 1976·Biochimica Et Biophysica Acta·C Ouyang, C M Teng
Oct 1, 1992·Toxicon : Official Journal of the International Society on Toxinology·B S Basavarajappa, T V Gowda
Jan 1, 1991·Toxicon : Official Journal of the International Society on Toxinology·A S Babu, T V Gowda
Oct 29, 1991·Biochemistry·E W DavieW Kisiel
Jan 1, 1991·Toxicon : Official Journal of the International Society on Toxinology·A S KamigutiC R Hay
Jan 1, 1991·Critical Reviews in Toxicology·J Meier, K Stocker
Jan 1, 1989·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·N H TanC S Tan
Jan 1, 1989·Toxicon : Official Journal of the International Society on Toxinology·G P JayanthiT V Gowda
Nov 15, 1989·Archives of Biochemistry and Biophysics·E N BaramovaJ W Fox
Jan 1, 1988·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·N H Tan, C S Tan
Nov 1, 1988·The Journal of Clinical Investigation·J I WeitzT Eckhardt
Jan 1, 1988·Toxicon : Official Journal of the International Society on Toxinology·G P Jayanthi, T V Gowda
Jun 1, 1969·Toxicon : Official Journal of the International Society on Toxinology·K W Denson
Dec 1, 1995·Toxicon : Official Journal of the International Society on Toxinology·M SugikiD G Theakston
Jan 1, 1996·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·M A FaizD Mantle
Jul 9, 1998·Toxicon : Official Journal of the International Society on Toxinology·E Beer, F Putorti
Dec 5, 1998·Toxicon : Official Journal of the International Society on Toxinology·F S Markland
Mar 10, 2000·Biochimica Et Biophysica Acta·T MatsuiK Titani
Apr 25, 2000·Toxicon : Official Journal of the International Society on Toxinology·D ChakrabartyD Bhattacharyya
Nov 22, 2000·Biochimie·S BraudA Wisner
Dec 12, 2001·Toxicon : Official Journal of the International Society on Toxinology·Steven D Aird
Jan 31, 2002·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·A K Mukherjee, C R Maity
May 16, 2002·The Journal of Peptide Research : Official Journal of the American Peptide Society·R R J ShelkeT V Gowda
Jul 2, 2002·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Yang JinYu-Liang Xiong
Aug 15, 2002·Toxicon : Official Journal of the International Society on Toxinology·D K JagadeeshaK Kemparaju
Oct 8, 2003·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Arinos MagalhaesEladio F Sanchez
Oct 16, 2003·Toxicon : Official Journal of the International Society on Toxinology·I B SundellR D G Theakston
Mar 17, 2004·Toxicon : Official Journal of the International Society on Toxinology·Teresa EscalanteJosé María Gutiérrez
Aug 18, 2004·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·L T GarcíaH S Selistre-de-Araujo
Dec 14, 2004·Acta Biochimica Et Biophysica Sinica·Dëora F VieiraRaghuvir K Arni
Jan 25, 2005·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Alessandra L CecchiniAndreimar M Soares
May 11, 2005·Toxicon : Official Journal of the International Society on Toxinology·S Swenson, F S Markland
Jun 1, 2005·Toxicon : Official Journal of the International Society on Toxinology·Julian White
Jun 1, 2005·Toxicon : Official Journal of the International Society on Toxinology·Gavin D Laing, Ana M Moura-da-Silva
Jun 1, 2005·Toxicon : Official Journal of the International Society on Toxinology·R Manjunatha Kini
Jun 1, 2005·Toxicon : Official Journal of the International Society on Toxinology·Neville Marsh, Vaughan Williams

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Citations

May 21, 2011·Toxicon : Official Journal of the International Society on Toxinology·Ana M SalazarBelsy Guerrero
Mar 13, 2018·Journal of Cellular Biochemistry·Raghavendra GowdaVishwanath Bannikuppe Sannanayak
Nov 6, 2007·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Qiuyan ZhangYongming Bao
Aug 1, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·David Meléndez-MartínezCuauhtémoc Licona-Cassani

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