PMID: 2116906Jul 20, 1990Paper

Differential action of thyroid hormones and chemically related compounds on the activity of UDP-glucuronosyltransferases and cytochrome P-450 isozymes in rat liver

Biochimica Et Biophysica Acta
H GoudonnetR C Truchot

Abstract

The effect of thyroid hormones and chemically related compounds, on the activity of UDP-glucuronosyltransferases (EC 2.4.1.17) and cytochrome P-450-dependent monooxygenases in rat liver microsomes was investigated. The animals were thyroidectomized and treated with different doses of the drugs for 3 weeks. Opposite effects were observed depending on the isoenzyme of UDP-glucuronosyltransferase considered. While 3,3',5-triiodo-L-thyronine, 3,3',5-triiodothyroacetic acid, 3,3',5-triiodothyropropionic acid, isopropyldiiodothyronine and L- and D-thyroxine strongly increased 4-nitrophenol glucuronidation in a dose-dependent fashion, they decreased markedly bilirubin glucuronidation. However, the activity toward nopol, a monoterpenoid alcohol, was not significantly changed regardless of which compound or dose was used. Variation of UDP-glucuronosyltransferase observed with 4-nitrophenol and bilirubin was related to the thyromimetic effect of the drugs estimated from the increase in alpha-glycerophosphate dehydrogenase. Thyronine and 3,5-diiodo-L-tyrosine, which did not enhance this activity, also failed to affect glucuronidation. Variations in UDP-glucuronosyltransferase activity were more likely due to changes in protein expression ...Continue Reading

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Citations

Apr 6, 2012·European Journal of Drug Metabolism and Pharmacokinetics·Jean-Marie HeydelYves Artur
Apr 24, 2001·Pharmacology & Therapeutics·K GrancharovE Golovinsky
May 9, 2002·Molecular and Cellular Endocrinology·Valérie HaberkornHervé Goudonnet
May 13, 2010·Drug Metabolism and Pharmacokinetics·Yuji IshiiHideyuki Yamada
Feb 24, 2018·Nature Reviews. Endocrinology·Rohit A SinhaPaul M Yen
Aug 2, 2008·The Journal of Toxicological Sciences·Ena LeeHyung Sik Kim

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