Differential actions of calcium antagonists on calcium binding to cardiac sarcolemma

European Journal of Pharmacology
D C Pang, N Sperelakis

Abstract

The action of four calcium antagonistic drugs, including verapamil, bepridil, nifedipine, and diltiazem, on calcium binding to cardiac sarcolemma from guniea pig was tested. It was found that verapamil (10(-6) to 10(-5) M) inhibited calcium binding to a great extent. Bepridil at the same concentrations was less potent than verapamil in the depression of calcium binding. Nifedipine and diltiazem did not affect sarcolemmal calcium binding. The differential action of the calcium antagonistic drugs was discussed.

References

Jan 1, 1977·Annual Review of Pharmacology and Toxicology·A Fleckenstein
Nov 1, 1978·Journal of Molecular and Cellular Cardiology·M Kohlhardt, Z Mnich
Jul 18, 1977·Naunyn-Schmiedeberg's Archives of Pharmacology·M Kohlhardt, A Fleckenstein
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Mar 1, 1980·Canadian Journal of Physiology and Pharmacology·J Church, T T Zsotér

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Citations

Jan 22, 1985·European Journal of Pharmacology·M Spedding, C Berg
Jan 28, 1987·European Journal of Pharmacology·J WattsT Harwell
May 1, 1986·British Journal of Pharmacology·P A Molyvdas, N Sperelakis
Nov 1, 1983·British Journal of Pharmacology·M Spedding
Dec 1, 1986·The American Journal of Physiology·D M BersY Kim
Jul 15, 1984·Biochemical Pharmacology·A Erdreich, H Rahamimoff
Apr 15, 1984·Biochemical Pharmacology·A Younes, J M Schneider

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