Differential activation of natriuretic peptide receptors modulates cardiomyocyte proliferation during development

Development
Jason R BeckerCalum A Macrae

Abstract

Organ development is a highly regulated process involving the coordinated proliferation and differentiation of diverse cellular populations. The pathways regulating cell proliferation and their effects on organ growth are complex and for many organs incompletely understood. In all vertebrate species, the cardiac natriuretic peptides (ANP and BNP) are produced by cardiomyocytes in the developing heart. However, their role during cardiogenesis is not defined. Using the embryonic zebrafish and neonatal mammalian cardiomyocytes we explored the natriuretic peptide signaling network during myocardial development. We observed that the cardiac natriuretic peptides ANP and BNP and the guanylate cyclase-linked natriuretic peptide receptors Npr1 and Npr2 are functionally redundant during early cardiovascular development. In addition, we demonstrate that low levels of the natriuretic peptides preferentially activate Npr3, a receptor with Gi activator sequences, and increase cardiomyocyte proliferation through inhibition of adenylate cyclase. Conversely, high concentrations of natriuretic peptides reduce cardiomyocyte proliferation through activation of the particulate guanylate cyclase-linked natriuretic peptide receptors Npr1 and Npr2, an...Continue Reading

References

Mar 3, 1988·Nature·T SudohH Matsuo
Aug 1, 1996·Journal of Molecular and Cellular Cardiology·F LiA M Gerdes
Feb 7, 1998·Proceedings of the National Academy of Sciences of the United States of America·P M OliverN Maeda
Jun 11, 1999·The Journal of Biological Chemistry·K S Murthy, G M Makhlouf
Jun 23, 1999·Proceedings of the National Academy of Sciences of the United States of America·N MatsukawaO Smithies
Mar 29, 2000·Proceedings of the National Academy of Sciences of the United States of America·N TamuraM Katsuki
Sep 15, 2000·Bioorganic & Medicinal Chemistry Letters·C A VealeE P Vacek
Feb 13, 2001·European Journal of Pharmacology·A NirY Hasin
Dec 17, 2003·The Journal of Biological Chemistry·Chee Chew LimDouglas B Sawyer
Mar 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Thomas H LangenickelMichael Bader
Mar 21, 2007·Nature Methods·Ethan K ScottHerwig Baier
May 4, 2007·Biochemical and Biophysical Research Communications·Douglas G JohnsStephen A Douglas
May 29, 2007·PLoS Genetics·Mara E RobuStephen C Ekker
Jan 15, 2008·Nature Protocols·Christine Thisse, Bernard Thisse
Feb 15, 2008·American Journal of Physiology. Cell Physiology·M WilliamH H Rasmussen
Oct 3, 2008·The Journal of Clinical Investigation·Risto KerkelaGordon S Huggins
Feb 13, 2009·American Journal of Physiology. Cell Physiology·Lamis HammoudQingping Feng
Sep 29, 2009·Biochimica Et Biophysica Acta·Nicola J A ScottVicky A Cameron

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Citations

Jun 23, 2015·Differentiation; Research in Biological Diversity·Gianfranco MatroneMartin A Denvir
Sep 2, 2015·Current Treatment Options in Cardiovascular Medicine·Arun SharmaSean M Wu
Dec 3, 2014·Clinica Chimica Acta; International Journal of Clinical Chemistry·Alessia Buglioni, John C Burnett
Dec 15, 2017·Cellular and Molecular Life Sciences : CMLS·Ayano ChibaNaoki Mochizuki
Jan 19, 2018·Journal of Biological Engineering·Shihui FuLeiming Luo
Aug 27, 2019·Current Topics in Medicinal Chemistry·Shihui FuJuelin Deng
May 13, 2017·JACC. Basic to Translational Science·Laura M G Meems, John C Burnett

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