Differential activation of spinal dorsal horn units by subcutaneous formalin injection in the cat: an electrophysiological study

Experimental Brain Research
J Chen, N Koyama

Abstract

In our previous report we found that subcutaneous (s.c.) formalin injection into the cutaneous receptive field (RF) of dorsal horn wide-dynamic-range (WDR) units and nociceptive primary afferent units resulted in a tonic, long-lasting increase in firing. However, s.c. formalin injection only resulted in a short-lasting increase in firing of non-nociceptive primary afferent units. In the present study, by using extracellular single-unit recording techniques we further studied effects of s.c. formalin on response properties of identified superficial-layer nociceptive-specific (NS) units and deeper-layer, low-threshold mechanoreceptive (LTM) units of L7 dorsal horn in urethane-chloralose-anesthetized cats. s.c. formalin injection into the RF of NS units resulted in a tonic, long-lasting increase in firing (7.08+/-0.42 spikes/s, n = 5), for more than 1 h, compared with the spontaneous background (1.42+/-0.03 spikes/s, n = 5). Formalin injection into the RF of LTM units also resulted in an increase in firing; however, the duration was short-lasting, for 25-520 s (152.92+/-46.73 s, n = 12). The present study demonstrated that s.c. injection of dilute formalin solution resulted in activation of not only nociceptive but also non-nocice...Continue Reading

Citations

Aug 3, 2006·The American Journal of Chinese Medicine·Jae Hyo KimByung Rim Park
Jun 19, 2010·Progress in Neurobiology·Jun Chen, William R Lariviere
Feb 11, 2000·Journal of Science and Medicine in Sport·C FrankD Hart

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