PMID: 8584232Oct 13, 1995Paper

Differential activation of the 5-hydroxytryptamine-containing neurons of the midbrain raphe of the rat in response to randomly presented inescapable sound

Neuroscience Letters
R P Dilts, M C Boadle-Biber

Abstract

Estimates of 5-hydroxytryptamine (5-HT) turnover in response to 30 min of inescapable, randomly presented, loud sound (sound stress) were obtained for regions of rat brain containing 5-HT perikarya by means of 5-hydroxytryptophan (5-HTP) accumulation after administration of an inhibitor of aromatic amino acid decarboxylase (100 mg/kg i.p., m-hydroxybenzylhydrazine, NSD 1015). Sound stress increased 5-HTP accumulation in the median raphe nucleus (MRN) twofold over that from sham-stressed controls, but did not change 5-HTP accumulation significantly in dorsal raphe nucleus (DRN) or hindbrain. These findings indicate that the 5-HT perikarya of the MRN but not those of the DRN or hindbrain are activated by sound stress, thus, provide further evidence for a functional distinction between the 5-HT neurons of these two midbrain nuclei.

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Citations

Apr 20, 2004·Progress in Neuro-psychopharmacology & Biological Psychiatry·Sevda Bulduk, Resit Canbeyli
Oct 7, 1998·Progress in Neurobiology·N Singewald, A Philippu
Oct 13, 2001·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·M W Gittos, M Papp
Dec 17, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Julia C LemosSheryl G Beck
Dec 24, 1998·British Journal of Pharmacology·A Adell, F Artigas
Mar 26, 2014·Neuroscience and Biobehavioral Reviews·Evan D PaulChristopher A Lowry
Jun 26, 2008·European Journal of Pharmacology·Andrew K EvansChristopher A Lowry
Apr 25, 2006·Nuclear Medicine and Biology·Arata WatanabeMirko Diksic
Jul 13, 2000·Journal of Psychopharmacology·F Chaouloff

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