PMID: 16520297Mar 8, 2006Paper

Differential activity of lipoic acid enantiomers in cell culture

Journal of Herbal Pharmacotherapy
Jerry Robert SmithKeith K Parker

Abstract

It is unclear whether the two enantiomeric forms (R & S) of lipoic acid (LA) share similar pharmacological activity and the exact cellular targets of LA are not well identified. We oxidatively stressed 3 cell culture systems representing different cell types. Mitochondrial metabolism was the primary endpoint. When C6 glioma was damaged by hydrogen peroxide (H2O2), all forms of LA protected. Racemic and S-LA were less effective than the R-isomer that was also protective in tertiary butyl hydroperoxide (TBHP)-damaged C6 glioma. In PC12 cells, little damage was produced by TBHP; R-LA increased mitochondrial metabolism above the level of non-damaged control. In H2O2 damaged PC12 cells, R-LA and racemic LA (but not S-LA) not only protected against damage, but increased mitochondrial metabolism above the non-damaged control level. When BAE cells were damaged with H2O2, R- and racemic LA protected while S-LA was ineffective.

References

Apr 11, 1980·Science·K K ParkerA Vernadakis
Aug 1, 1995·Free Radical Biology & Medicine·L PackerH J Tritschler
Mar 8, 1995·Biochemical and Biophysical Research Communications·S MatsugoL Packer
Nov 23, 2000·Nature·T Finkel, N J Holbrook
Mar 3, 2004·Archives of Biochemistry and Biophysics·Bruce N Ames

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Citations

May 11, 2012·Journal of Clinical Biochemistry and Nutrition·Masao YamasakiKazuo Nishiyama
Apr 8, 2014·Chemico-biological Interactions·Shimaa Omar AliNabila Abd El-fattah Ismail
Nov 3, 2010·The Journal of Nutritional Biochemistry·Sonemany SalinthoneDaniel W Carr
Sep 8, 2015·Biochimica Et Biophysica Acta·Sylvia HillerXianwen Yi
Jan 24, 2006·Journal of Ethnopharmacology·Ava RhuleDavid M Shepherd
Feb 28, 2013·International Journal of Molecular Sciences·Daniele TomassoniSeyed Khosrow Tayebati

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