Differential activity of matrix metalloproteinases (MMPs) during photoperiod induced uterine regression and recrudescence in Siberian hamsters (Phodopus sungorus).

Molecular Reproduction and Development
Asha Shahed, Kelly A Young

Abstract

Siberian hamsters adapt to seasonal changes by reducing their reproductive function during short days (SD). SD exposure reduces uterine mass and reproductive capacity, but underlying cellular mechanisms remain unknown. Because matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) are important in uterine development, parturition, and postpartum remodeling, their expression in uterine tissue from Siberian hamsters undergoing photoperiod-mediated reproductive regression and recrudescence was investigated. Female hamsters were exposed to long day (LD, 16L:8D, controls) or SD (8L:16D) for 3-12 weeks (regression); a second group was exposed to SD or LD for 14 weeks and then transferred to LD for 0-8 weeks (recrudescence). Hamsters were euthanized, uteri collected, and homogenates analyzed by gelatin zymography or Western blotting for MMP and TIMP protein levels. Uterine weight decreased (67-75%) at SD weeks 12-14 and increased post-LD transfer (PT) reaching LD values by PT week 2. MMP-2, but not MMP-9 activity was reduced by SD week 12 or 14 but increased to LD levels at PT week 2. MMP-3 expression increased at SD week 9 compared to other SD and LD groups. MMP-14 and -13 protein levels decreased at SD week 3 but retur...Continue Reading

References

Feb 1, 1985·The Journal of Endocrinology·H ShimadaT Mori
Feb 1, 1986·The American Journal of Physiology·A J Morton, D F Goldspink
Sep 1, 1969·Biology of Reproduction·M J HarperA S Elliott
Dec 1, 1966·Journal of Reproduction and Fertility·K Yoshinaga, C E Adams
Nov 1, 1993·General and Comparative Endocrinology·K E Edmonds, M H Stetson
Mar 1, 1997·Matrix Biology : Journal of the International Society for Matrix Biology·U Benbow, C E Brinckerhoff
Jan 26, 1999·Annals of the New York Academy of Sciences·Z Werb, J R Chin
Sep 24, 1999·Biology of Reproduction·S FreitasM Perrot-Applanat
Nov 29, 2002·Proceedings of the National Academy of Sciences of the United States of America·Brian J PrendergastRandy J Nelson
Apr 9, 2004·Biology of Reproduction·Hedley A CoppockMelissa Westwood
May 28, 2004·Biology of Reproduction·Ned J PlaceIrving Zucker
Jul 9, 2004·Biology of Reproduction·Jianbo HuThomas E Spencer
Jun 10, 2005·Biology of Reproduction·Tu'uhevaha J Kaitu'uLois A Salamonsen
Jul 8, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Zezong GuStuart A Lipton
Jan 27, 2006·Reproductive Biology and Endocrinology : RB&E·Fei SunRenée H Martin
Apr 6, 2006·Reproduction : the Official Journal of the Society for the Study of Fertility·C S Moffatt-BlueKelly A Young
Sep 13, 2006·Molecular Reproduction and Development·Xuan ZhangWarren B Nothnick
Sep 28, 2006·The American Journal of Pathology·Karim Si-TayebJean Rosenbaum
Feb 24, 2007·Nature Reviews. Molecular Cell Biology·Andrea Page-McCawZena Werb
Jan 1, 1996·Trends in Endocrinology and Metabolism : TEM·L A Salamonsen

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Citations

Oct 1, 2010·Reproduction : the Official Journal of the Society for the Study of Fertility·Julie WhitedKelly A Young

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