Differential acute effects of oxovanadiums and insulin on glucose and lactate metabolism under in vivo and in vitro conditions

Metabolism: Clinical and Experimental
J LiuS Ganguli

Abstract

Oxovanadium compounds such as vanadate and peroxovanadiums have been shown to have insulin-mimetic effects on various metabolic pathways, including glucose metabolism. A differential effect of various oxovanadium species on glucose metabolism in different tissues has been reported. The results from our present in vivo studies using rats show that peroxovanadiums and insulin have similar acute effects on decreasing blood glucose levels, but dissimilar effects on blood lactate levels. Furthermore, when bisperoxovanadate (BPV) was administered acutely to intact animals immediately before a bolus insulin challenge, it blunted the effectiveness of insulin in decreasing the blood lactate level, but at the same time demonstrated a synergistic effect on the hypoglycemic action of insulin. It was also observed in in vitro studies using normal 3T3-L1 adipocytes (not serum-deprived) that 1,10-phenanthroline bisperoxovanadate (PHEN-BPV) attenuates the incorporation of carbon from lactate but not from glucose, into lipid in both the absence and presence of insulin. Additionally, it was observed that PHEN-BPV had no effect on lactate dehydrogenase (LDH) activity. Thus, one may speculate that PHEN-BPV interferes with carrier-mediated lactate ...Continue Reading

References

Apr 1, 1992·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·M DiGirolamoJ Lovejoy
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Aug 1, 1982·Biochemical and Biophysical Research Communications·G SwarupD L Garbers
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Nov 1, 1994·Metabolism: Clinical and Experimental·S GanguliM Tucker
Apr 15, 1994·The Biochemical Journal·F Wibrand, C Juel
Apr 1, 1996·The American Journal of Physiology·G Faintrenie, A Géloën

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Citations

Jan 26, 2018·Basic & Clinical Pharmacology & Toxicology·Geir BjørklundRoman Lysiuk
May 20, 2016·The Cochrane Database of Systematic Reviews·Barbara WiderEdzard Ernst

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