Differential adhesive properties of sequestered asexual and sexual stages of Plasmodium falciparum on human endothelial cells are tissue independent.

PloS One
F SilvestriniP Alano

Abstract

The protozoan parasite Plasmodium falciparum, responsible for the most severe form of malaria, is able to sequester from peripheral circulation during infection. The asexual stage parasites sequester by binding to endothelial cell receptors in the microvasculature of various organs. P. falciparum gametocytes, the developmental stages responsible for parasite transmission from humans to Anopheles mosquitoes, also spend the almost ten days necessary for their maturation sequestered away from the peripheral circulation before they are released in blood mainstream. In contrast to those of asexual parasites, the mechanisms and cellular interactions responsible for immature gametocyte sequestration are largely unexplored, and controversial evidence has been produced so far on this matter. Here we present a systematic comparison of cell binding properties of asexual stages and immature and mature gametocytes from the reference P. falciparum clone 3D7 and from a patient parasite isolate on a panel of human endothelial cells from different tissues. This analysis includes assays on human bone marrow derived endothelial cell lines (HBMEC), as this tissue has been proposed as a major site of gametocyte maturation. Our results clearly demon...Continue Reading

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Citations

Dec 14, 2012·Future Medicinal Chemistry·Leonardo Lucantoni, Vicky Avery
Jul 11, 2014·Science Translational Medicine·Regina JoiceMatthias Marti
Dec 25, 2012·Malaria Journal·Steven B MwakalingaThomas Lavstsen
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Apr 1, 2015·Trends in Parasitology·Marta TibúrcioPietro Alano
Jun 19, 2015·PLoS Pathogens·Sandra K NilssonMatthias Marti
Apr 11, 2013·Proceedings of the National Academy of Sciences of the United States of America·Hiromi IkadaiMarcelo Jacobs-Lorena
Nov 12, 2016·Cold Spring Harbor Perspectives in Medicine·Elamaran Meibalan, Matthias Marti
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Dec 17, 2019·Immunological Reviews·Roos M de JongTeun Bousema
Jan 11, 2020·Nature Reviews. Microbiology·Kannan VenugopalMatthias Marti
Apr 10, 2019·Infection and Immunity·Festus K AcquahLinda E Amoah
Mar 17, 2018·Frontiers in Cellular and Infection Microbiology·Valeria MessinaFrancesco Silvestrini
Dec 4, 2019·Frontiers in Microbiology·Gaëlle Neveu, Catherine Lavazec
Feb 26, 2019·Frontiers in Immunology·Jonas A Kengne-OuafoBismarck Dinko
Jun 21, 2019·FEMS Microbiology Reviews·Priscilla NgothoMatthias Marti
Feb 26, 2021·Current Opinion in Hematology·Gaëlle Neveu, Catherine Lavazec
Jul 13, 2021·Frontiers in Cellular and Infection Microbiology·Luis Carlos Salazar AlvarezStefanie Costa Pinto Lopes

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Methods Mentioned

BETA
fluorescence-activated cell sorting
FACS

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