Differential adipokine receptor expression on circulating leukocyte subsets in lean and obese children

PloS One
Genoveva KeustermansHenk S Schipper

Abstract

Childhood obesity prevalence has increased worldwide and is an important risk factor for type 2 diabetes (T2D) and cardiovascular disease (CVD). The production of inflammatory adipokines by obese adipose tissue contributes to the development of T2D and CVD. While levels of circulating adipokines such as adiponectin and leptin have been established in obese children and adults, the expression of adiponectin and leptin receptors on circulating immune cells can modulate adipokine signalling, but has not been studied so far. Here, we aim to establish the expression of adiponectin and leptin receptors on circulating immune cells in obese children pre and post-lifestyle intervention compared to normal weight control children. 13 obese children before and after a 1-year lifestyle intervention were compared with an age and sex-matched normal weight control group of 15 children. Next to routine clinical and biochemical parameters, circulating adipokines were measured, and flow cytometric analysis of adiponectin receptor 1 and 2 (AdipoR1, AdipoR2) and leptin receptor expression on peripheral blood mononuclear cell subsets was performed. Obese children exhibited typical clinical and biochemical characteristics compared to controls, includ...Continue Reading

References

Jul 21, 2000·The Journal of Clinical Endocrinology and Metabolism·A KatzM J Quon
Jun 26, 2003·Clinical and Experimental Immunology·V Sánchez-MargaletC Gonzalez-Yanes
Mar 30, 2007·Diabetes, Obesity & Metabolism·L AlbertiC Invitti
Dec 7, 2007·The New England Journal of Medicine·Jennifer L BakerThorkild I A Sørensen
Jan 6, 2009·Annals of the New York Academy of Sciences·Terence T L Pang, Parth Narendran
Jun 10, 2010·Clinical Chemistry·Henk S SchipperEric Kalkhoven
Jan 22, 2011·Nature Reviews. Immunology·Noriyuki OuchiKenneth Walsh
Nov 2, 2011·International Journal of Obesity : Journal of the International Association for the Study of Obesity·L J LloydS McMullen
Jan 13, 2012·Circulation. Cardiovascular Genetics·Katarina E BergHarry Björkbacka
Dec 12, 2012·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·J L RourkeC J Sinal
Jan 29, 2013·Cell Metabolism·Toshimasa Yamauchi, Takashi Kadowaki
Oct 24, 2013·Frontiers in Immunology·Claudio ProcacciniGiuseppe Matarese
Nov 26, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Donte C SaucilloNancie J Maciver
Jan 15, 2014·Best Practice & Research. Clinical Endocrinology & Metabolism·Toshimasa YamauchiTakashi Kadowaki
Apr 22, 2014·Trends in Endocrinology and Metabolism : TEM·Koji OhashiNoriyuki Ouchi
Nov 14, 2014·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Caroline M W van StijnRajendra K Tangirala
Apr 29, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Bernardo S ReisDaniel Mucida
Nov 8, 2015·Vascular Pharmacology·Mario Bonomini, Assunta Pandolfi
Nov 19, 2015·Frontiers in Physiology·Leandro C Freitas LimaCamille de Moura Balarini
Jan 19, 2016·Trends in Molecular Medicine·Caitlin Naylor, William A Petri
Feb 10, 2016·Obesity·Daniela FrascaBonnie B Blomberg
Apr 14, 2016·The New England Journal of Medicine·Gilad TwigJeremy D Kark
Aug 23, 2016·Vaccine·Wei FanChen Dong
Jan 6, 2017·Nature Reviews. Rheumatology·Vanessa AbellaOreste Gualillo

❮ Previous
Next ❯

Citations

Dec 26, 2018·Journal of Immunology Research·Piero RuscittiRoberto Giacomelli
Apr 2, 2020·Frontiers in Immunology·Ina BährHeike Kielstein
Mar 22, 2018·Immunologic Research·Ina BährHeike Kielstein
Jul 9, 2020·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Paulina ŻelechowskaElżbieta Kozłowska
Oct 27, 2020·Current Opinion in Pediatrics·Xingyuan FangSarah E Henrickson
May 18, 2021·Frontiers in Neuroscience·Nicolas JacquelotCyril Seillet

❮ Previous
Next ❯

Datasets Mentioned

BETA
GO25H7

Methods Mentioned

BETA
flow cytometry
density gradient centrifugation

Software Mentioned

xPONENT
Plex Manager
SPSS
Bio

Related Concepts

Related Feeds

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.