Differential age-related changes of hypothalamus - pituitary - adrenal axis hormones in healthy women and men - role of interleukin 6

Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association
B ZietzR H Straub

Abstract

Aging is accompanied by marked changes of steroid hormone levels which vary among women and men. The age-related increase of cytokines such as interleukin (IL)- 6 may modulate the endocrine system. We aimed to investigate the role of IL-6 for the gender-specific changes of acrophase steroid hormone secretion in healthy subjects during aging. Out of 120 healthy subjects, 60 men and 48 women (non luteal phase) were recruited (age: 18 to 75 years). Age was positively correlated with IL-6 (female and male: p<0.001) and adrenocorticotropic hormone (ACTH) in women only (p<0.001). Age was negatively correlated with progesterone (female and male: p<0.001), cortisol (only female: p=0.003), androstenedione (female and male: p<0.001), but not 17OH progesterone. After correction for IL-6, the age-related decrease of steroid hormones was blunted in both gender groups except for androstenedione (female and male: p<0.005). Furthermore, the ratio of serum cortisol to plasma ACTH decreased with age only in women but not in men (female: p< 0.001). Correction for IL-6 did not markedly change the negative interrelationship between age and the mentioned ratio in these women. However, a linear regression analysis revealed that the increase of ACTH i...Continue Reading

Citations

Sep 25, 2012·Pflügers Archiv : European journal of physiology·Sung Ryul LeeJin Han
Aug 21, 2001·Mechanisms of Ageing and Development·R H StraubJ Schölmerich
Jul 13, 2002·Annals of the New York Academy of Sciences·Candida SilvaJose Antonio P da Silva
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Dec 12, 2018·Journal of Alzheimer's Disease : JAD·André de Macêdo Medeiros, Regina Helena Silva

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