Differential alteration of neuronal and cardiovascular responses to adenosine microinjected into the nucleus tractus solitarius of spontaneously hypertensive rats

Hypertension
A A Abdel-Rahman, S Tao

Abstract

We previously reported that adenosine elicited site-dependent neuronal and cardiovascular responses in two subareas of the nucleus tractus solitarius (NTS) of normotensive rats. Pressor and tachycardic responses were obtained from the rostral NTS (adenosine pressor system), and depressor and bradycardic responses were obtained from the caudal NTS (adenosine depressor system). In both areas, adenosine inhibited the firing rate of barosensitive neurons. The present study investigated whether spontaneously hypertensive rats (SHR) exhibit abnormal neuronal and cardiovascular responses mediated by the adenosine pressor and depressor systems within the NTS. Male SHR and Wistar-Kyoto rats (WKY) were anesthesized with urethane and prepared for blood pressure and heart rate recording, stereotaxic microinjection of adenosine into the NTS, and extracellular recording of single-unit neuronal activity of NTS neurons. Chemical identification of the targeted neuronal pool was made by L-glutamate (5 nmol) and confirmed by histology. SHR exhibited significantly higher mean arterial pressure and firing rate of caudal NTS neurons (45.0 +/- 4.5 versus 27.3 +/- 4.7 spikes per 2.5 seconds, P <.05) but similar heart rate and neuronal firing rate of r...Continue Reading

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Citations

Oct 2, 2002·European Journal of Pharmacology·Moez RekikAbdel A Abdel-Rahman
Jun 5, 1997·European Journal of Pharmacology·A J LawrenceB Jarrott
Apr 2, 1999·Trends in Pharmacological Sciences·J W Nyce
Jul 21, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Tomoko K IchinoseTadeusz J Scislo
Apr 8, 1999·European Journal of Pharmacology·D V SivaraoP J Hornby
Aug 11, 2015·Journal of Advanced Research·Noha N Nassar, Abdel A Abdel-Rahman
Nov 13, 2013·Autonomic Neuroscience : Basic & Clinical·Zeljka MinicTadeusz J Scislo
Dec 4, 2014·Autonomic Neuroscience : Basic & Clinical·Fernando E SantiagoDaniel C Carrettiero
Apr 6, 2006·The Journal of Pharmacology and Experimental Therapeutics·Noha Nassar, Abdel A Abdel-Rahman
Jul 27, 2014·American Journal of Physiology. Heart and Circulatory Physiology·Zeljka MinicTadeusz J Scislo
Apr 26, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Zeljka MinicTadeusz J Scislo
Jun 14, 2000·American Journal of Physiology. Heart and Circulatory Physiology·A M KitchenD S O'Leary
Jun 14, 2000·American Journal of Physiology. Heart and Circulatory Physiology·T J Scislo, D S O'Leary
Dec 9, 1998·The American Journal of Physiology·T J Scislo, D S O'Leary

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