PMID: 9450648Feb 5, 1998Paper

Differential alterations in metabolic pattern of the six major UsnRNAs during development

Molecular and Cellular Biochemistry
R RayC K Panda

Abstract

The uridylic acid rich nuclear RNAs (U1-U6 snRNAs) are involved mainly in the processing of pre-mRNA and pre-rRNA. So, any control of cell growth through pre-mRNA/pre-rRNA processing may have some regulation through altered UsnRNAs metabolism. With this idea, attempts have been made to see how the metabolism of the six major UsnRNAs' changed during the normal process of cellular proliferation associated with differentiation from pluripotent/totipotent stem cells of early embryonic stage to much more differentiated state of different cell/tissue lineages in different tissues/organs during the fetal and neonatal stages of growth. It has been seen that the levels of the six major UsnRNAs were high in day 8 embryo when the cells were mainly pluripotent/totipotent in nature, and during the progression of embryonic development the levels of these UsnRNAs gradually decreased (approximately 35-65%) up to the midgestational period (day 13) with some exception, when the organogenesis has already been started. However in the fetal life, the levels of these UsnRNAs were maximum or comparable around 18 +/- 2 days of gestation in comparison to that in day 8 embryo when the kinetics of the maturational status of the different organs were quit...Continue Reading

Citations

Dec 14, 2018·International Journal of Molecular Sciences·Nolan T CarewChristine Milcarek
Aug 5, 2020·Proceedings of the National Academy of Sciences of the United States of America·Weili WangYunfeng Liu
Oct 10, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ashley M NelsonChristine Milcarek
Aug 16, 2005·The Plant Journal : for Cell and Molecular Biology·Misato Ohtani, Munetaka Sugiyama
Dec 3, 2016·Journal of Plant Research·Misato Ohtani
Sep 7, 2017·RNA Biology·Pilar Vazquez-Arango, Dawn O'Reilly
Oct 17, 2006·Apoptosis : an International Journal on Programmed Cell Death·Sugata MannaChinmay Kr Panda

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